Immunohistological investigation of the potential role of pro-inflammatory biomarkers and revascularisation in the pathogenesis of ischemia reperfusion injury
- Conditions
- ischmemia/reperfusion injury
- Registration Number
- DRKS00007906
- Lead Sponsor
- niversitätsklinikum Freiburg
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete
- Sex
- All
- Target Recruitment
- 30
Inclusion Criteria
Patients undergoing reconstructive surgery procedures with free microvascular tissue transfer.
Exclusion Criteria
Underlying inflammatory diseases, elevated baseline values of circulating plasma CRP. Prior free flap failure.
Study & Design
- Study Type
- observational
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Detection of conformational changes of C-reactive protein in human tissue samples undergoing ischemia/reperfusion
- Secondary Outcome Measures
Name Time Method Detection of accumulation of cytokines and C-reactive protein in postischaemic tissue, correlating with the localized tissue inflammation.