Power Production in Older Adults With Knee Osteoarthritis Compared to Healthy Counterparts
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- KU Leuven
- 入组人数
- 48
- 试验地点
- 1
- 主要终点
- Rate of power development
研究概览
简要总结
Knee osteoarthritis is an important cause of functional disabilities at old age. Previous research has demonstrated that individuals with knee osteoarthritis have reduced knee-extensor strength in comparison to healthy individuals. However, rapid power production declines more than strength as a consequence of ageing and is more predictive of functional capacity. However, limited research has investigated whether individuals with knee osteoarthritis have reduced ability to develop strength and power rapidly on top of reduced maximal strength capacities, which is the primary aim of the current study.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Cross Sectional
入排标准
- 年龄范围
- 50 Years 至 80 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Group with knee osteoarthritis:
- •Diagnosed with knee osteoarthritis based on RX.
排除标准
- •Healthy group:
- •Systematic engagement in (resistance) exercise in the 12-months prior to participation
- •Cardiovascular disease
- •Neurological disorders
- •Cognitive malfunctioning
- •Severe knee or hip problems
- •Group with knee osteoarthritis:
- •Systematic engagement in (resistance) exercise in the 12-months prior to participation
- •Cardiovascular disease
- •Neurological disorders
- •Cognitive malfunctioning
- •Severe hip problems
结局指标
主要结局
Rate of power development
时间窗: up to 3 months
Subjects perform a test protocol on a Biodex dynamometer, consisting of isotonic contractions of the leg-extensor muscles. Subjects are instructed to kick as fast as possible against different (relative) loads. The rate of power development (watt/s) is defined as the linear slope of the power-time curve and is measured from the onset of movement till peak power.
次要结局
- Maximal isometric strength(up to 3 months)
- Handgrip strength(up to 3 months)
- Stair Climbing performance(up to 3 months)
- Gait speed(up to 3 months)
- Timed-up-and-go(up to 3 months)
- 5 repetition sit-to-stand test(up to 3 months)
- Maximal isokinetic strength(up to 3 months)