Power Production in Older Adults With Knee Osteoarthritis

Completed

• Conditions: Osteo Arthritis Knee
• Interventions: Diagnostic Test: Muscle function test

• Registration Number: NCT03680807
• Lead Sponsor: KU Leuven

Brief Summary

Knee osteoarthritis is an important cause of functional disabilities at old age. Previous research has demonstrated that individuals with knee osteoarthritis have reduced knee-extensor strength in comparison to healthy individuals. However, rapid power production declines more than strength as a consequence of ageing and is more predictive of functional capacity. However, limited research has investigated whether individuals with knee osteoarthritis have reduced ability to develop strength and power rapidly on top of reduced maximal strength capacities, which is the primary aim of the current study.

Detailed Description

Not available

Study Timeline

• Study Start: 2018-09-01
• Study First Submitted: 2018-09-18
• Study First Submitted QC: 2018-09-20
• Study First Posted: 2018-09-21
• Primary Completion: 2018-12-20
• Study Completion: 2018-12-20
• Status Verified: 2019-02
• Last Update Submitted: 2019-02-07
• Last Update Posted: 2019-02-08

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 48

Inclusion Criteria

Group with knee osteoarthritis:

• Diagnosed with knee osteoarthritis based on RX.

Exclusion Criteria

Healthy group:

• Systematic engagement in (resistance) exercise in the 12-months prior to participation
• Cardiovascular disease
• Neurological disorders
• Cognitive malfunctioning
• Severe knee or hip problems

Group with knee osteoarthritis:

• Systematic engagement in (resistance) exercise in the 12-months prior to participation
• Cardiovascular disease
• Neurological disorders
• Cognitive malfunctioning
• Severe hip problems

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
Healthy older adults (> 50 years)	Muscle function test	-
Older adults with knee osteoarthritis (>50 years)	Muscle function test	-

Primary Outcome Measures

Name	Time	Method
Rate of power development	up to 3 months	Subjects perform a test protocol on a Biodex dynamometer, consisting of isotonic contractions of the leg-extensor muscles. Subjects are instructed to kick as fast as possible against different (relative) loads. The rate of power development (watt/s) is defined as the linear slope of the power-time curve and is measured from the onset of movement till peak power.

Secondary Outcome Measures

Name	Time	Method
Maximal isometric strength	up to 3 months	Maximal strength (Nm) is measured by means of unilateral isometric knee-extensor tests on a Biodex dynamometer.
Handgrip strength	up to 3 months	Handgrip strength (kg) evaluated with Jamar dynamometer.
Gait speed	up to 3 months	The average speed to walk 10m as fast as possible (in m/s).
Timed-up-and-go	up to 3 months	The time needed to stand up from a chair, walk 3m, turn, walk back and sit down.
Maximal isokinetic strength	up to 3 months	Maximal strength (Nm) is measured by means of unilateral isokinetic knee-extensor tests on a Biodex dynamometer.
Stair Climbing performance	up to 3 months	Stair ascent duration (in s), the time needed to ascent a flight of stairs.
5 repetition sit-to-stand test	up to 3 months	The time needed to perform 5 sit-to-stand transitions (in s).

Trial Locations

Locations (1)

Department of Movement Sciences; 🇧🇪 Leuven, Belgium