Clinical significance of 18F-Sodium Fluoride uptake for cardiovascular calcification on Positron Emission Tomography
Not Applicable
Recruiting
- Conditions
- Aortic valve calcification, Aortic stenosis, Coronary plaque
- Registration Number
- JPRN-UMIN000031134
- Lead Sponsor
- Hiroshima University
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- All
- Target Recruitment
- 30
Inclusion Criteria
Not provided
Exclusion Criteria
1) Patients with bad general conditions, for example, immediately after cerebral hemorrhage. 2) Pregnant and lactating females (include possibility of them). 3) Claustrophobic patients. 4) Patients who are judged unsuitable for this study by the person in charge.
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method We compare 18F-Sodium Fluoride uptake of aortic valve, coronary artery, carotid artery and aorta on Positron Emission Tomography with coronary CT findings of aortic valve calcification, coronary calcification, and non-calcified and partial calcified plaques (positive remodeling, low attenuation plaque, spotty calcification and napkin-ring sign).
- Secondary Outcome Measures
Name Time Method We evaluate serial changes of aortic valve calcification on CT in 2-year period. We classify 18F-NaF uptake pattern of aortic valve into three groups in relation to CT-based calcification; overlapping with calcification, adjacent to calcification and distant from calcification. Additionally, we evaluate the location of aortic valve calcification (valve leaflet or ring). We assess the progression of aortic valve calcification and aortic valve stenosis in relative to 18F-NaF uptake value and uptake pattern.