18F-Sodium Fluoride uptake for cardiovascular calcificatio

Not Applicable

Recruiting

• Conditions: aortic valve stenosis; aortic valve calcification; D001024

• Registration Number: JPRN-jRCTs061180041
• Lead Sponsor: akano Yukiko

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2019-03-08
• Last Update Posted: 17 October 2023

Recruitment & Eligibility

• Status: Recruiting
• Sex: All
• Target Recruitment: 30

Inclusion Criteria

We include the patients with the following conditions.
1) Patients with coronary plaque (calcified plaque, non-calcified plaque and partial calcified plaque in >=2mm diameter coronary) or aortic valve calcification (CT value >=130HU) on coronary CT in Hiroshima University Hospital.
2) Patients over 30 years-old.
3) Patients without acute coronary syndrome and/or severe heart failure (within 3 months), or a unconscious condition.
4) Patients who agree with informed consent.

Exclusion Criteria

1) Patients with bad general conditions, for example, immediately after cerebral hemorrhage.
2) Pregnant and lactating females (include possibility of them).
3) Claustrophobic patients.
4) Patients who are judged unsuitable for this study by the person in charge.

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
We compare 18F-Sodium Fluoride uptake of aortic valve, coronary artery, carotid artery and aorta on Positron Emission Tomography with coronary CT findings of aortic valve calcification, coronary calcification, and non-calcified and partial calcified plaques (positive remodeling, low attenuation plaque, spotty calcification and napkin-ring sign).

Secondary Outcome Measures

Name	Time	Method
We evaluate serial changes of aortic valve calcification on CT in 2-year period.<br>We classify 18F-NaF uptake pattern of aortic valve into three groups in relation to CT-based calcification; overlapping with calcification, adjacent to calcification and distant from calcification. Additionally, we evaluate the location of aortic valve calcification (valve leaflet or ring). We assess the progression of aortic valve calcification and aortic valve stenosis in relative to 18F-NaF uptake value and uptake pattern.