A Genotype-Phenotype Urothelial Cancer Registry
试验速览
- 阶段
- 不适用
- 状态
- 进行中（未招募）
- 入组人数
- 3,519
- 试验地点
- 8
- 主要终点
- Determine whether single nucleotide polymorphisms in regions discovered from whole genome scans, such as 8q24 & chromosome 3, & candidate genes, include NAT2 & GSTM1, prev found to be assoc with bladder ca risk, are assoc with UC in this study population
研究概览
简要总结
This study is being done to create a registry to help us learn more about urinary and other cancers. This will let us look at large groups of people who do and do not have this kind of cancer.
The investigators will look at risk factors to learn more about how these impact cancer. The investigators will also look at genetic markers. These are genes that are found in a known place. They are often associated with a particular trait. If the gene changes in some way, it may predict cancer or response to treatment. The investigators will look for markers in your saliva.
This registry will help us develop better methods of:
Preventing these cancers. Diagnosing these cancers. Treating these cancers.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Urothelial Cancer Cases
- •Must be ≥ 18 years of age AND
- •Must have a diagnosis of urothelial cancer AND
- •Must be an English-speaker
- •Non-Cancer Control Group
- •Must be ≥ 18 years of age AND
- •Must not have cancer or a personal history of cancer, with the exception of skin cancer. AND
- •Must not be a blood relative of cases AND
- •Must not be a blood relative of another control AND
- •Must be an English-speaker
- •Family Member Control Group:
- •In select kindreds with a high prevalence of bladder cancer and/or very early onset bladder cancer, first- and second-degree family members of probands may be contacted by the MSKCC study team and invited to complete the questionnaire and submit a saliva sample.
- •Must be ≥ 18 years of age AND
- •Must be a blood relative of a case participant AND
- •Must be an English-speaker
排除标准
- •Have any condition, which in the opinion of the primary MSKCC clinician or investigators precludes their ability to provide informed consent.
结局指标
主要结局
Determine whether single nucleotide polymorphisms in regions discovered from whole genome scans, such as 8q24 & chromosome 3, & candidate genes, include NAT2 & GSTM1, prev found to be assoc with bladder ca risk, are assoc with UC in this study population
时间窗: 2 years
次要结局
- To determine whether single nucleotide polymorphisms in the genes and regions listed above are associated with outcomes after UC diagnosis in the population(2 years)