Kidney Cancer DNA Registry

Recruiting

• Conditions: Renal Cancer

• Registration Number: NCT02087852
• Lead Sponsor: Memorial Sloan Kettering Cancer Center

Brief Summary

This registry will help us develop better methods of:

* Preventing these cancers

* Diagnosing these cancers

* Treating these cancers

Detailed Description

Not available

Study Timeline

• Study Start: 2014-03
• Study First Submitted: 2014-03-12
• Study First Submitted QC: 2014-03-12
• Study First Posted: 2014-03-14
• Status Verified: 2024-10
• Last Update Submitted: 2024-10-11
• Last Update Posted: 2024-10-15
• Primary Completion: 2026-03
• Study Completion: 2026-03

Recruitment & Eligibility

• Status: RECRUITING
• Sex: All
• Target Recruitment: 750

Inclusion Criteria

Kidney Cancer Case Cohort:

• Must be ≥ 18 years of age AND
• Must be an English-speaker AND
• Must have a diagnosis or suspicion of kidney cancer

Family Member Cohort:

• Must be ≥ 18 years of age AND
• Must be an English-speaker AND
• Must be a blood relative of the proband. Family members of probands including mother, father, sisters, brothers, half-sisters, half-brothers, daughters, sons, grandmothers, grandfathers, as well as aunts and uncles are eligible. These individuals need not have kidney cancer, as they will be used for segregation analysis of suspected variants found in the proband; requesting DNA from relatives is required.

Control Cohort:

• Must be ≥ 18 years of age AND
• Must be an English-speaker AND
• Must not have a personal history of cancer, with the exception of nonmelanoma skin cancer, AND
• Must not be a blood relative of any cases or controls enrolled in this study

Exclusion Criteria

• Patients who, in the opinion of the primary MSKCC clinician or the investigator, have a condition that precludes their ability to provide an informed consent

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
establish a kidney cancer registry	5 years	with detailed epidemiologic data and germline DNA available for next generation sequencing from consenting patients, selected family members, and healthy unrelated controls.

Trial Locations

Locations (7)

Memorial Sloan Kettering at Basking Ridge (Consent and Follow-up); 🇺🇸 Basking Ridge, New Jersey, United States

Memorial Sloan Kettering Monmouth (Consent and Follow up); 🇺🇸 Middletown, New Jersey, United States

Memorial Sloan Kettering Bergen (Consent and Follow up ); 🇺🇸 Montvale, New Jersey, United States

Memorial Sloan Kettering Commack (Consent and Follow-up); 🇺🇸 Commack, New York, United States

Memorial Sloan Kettering Westchester (Consent and Follow up); 🇺🇸 Harrison, New York, United States

Memorial Sloan Kettering Cancer Center (All Protocol Activities); 🇺🇸 New York, New York, United States

Memorial Sloan Kettering Nassau (Consent and Follow-Up); 🇺🇸 Uniondale, New York, United States