Comparative study of effect of dexmedetomidine versus clonidine on hemodynamic stability and postoperative analgesia during laproscopic assisted vaginal hysterectomy.
试验速览
- 阶段
- 4 期
- 状态
- 已完成
- 发起方
- 入组人数
- 100
- 试验地点
- 1
- 主要终点
- To compare the outcome attenuation of hemodynamic response to pneumoperitonium and post operative analgesia during general anaesthesia in laparoscopic assisted general anaesthesia
研究概览
简要总结
Randomized clinical trial to study the effect of intravenous dexmedetomidine and intravenous clonidine on hemodynamic response to pneumoperitoneum during general anaeshesia and post opeative analgesic effect in laparoscopic assisted vaginal hysterectomy.
研究设计
- 研究类型
- Interventional
- 分配方式
- Computer generated randomization
- 盲法
- Participant and Investigator Blinded
入排标准
- 年龄范围
- 30.00 Year(s) 至 50.00 Year(s)（—）
- 性别
- Female
入选标准
- •ASA Physical status I and II.
- •Elective laparoscopic assisted vaginal hysterectomy.
排除标准
- •ASA physical status III,IV and V.
- •Patients with aortic stenosis.
- •Patient with history of congestive heart failure,liver disease,renal failure.
- •Patients with any degree of atrioventricular block.
- •Patients taking beta blocker and monoamine-oxidase inhibitors.
结局指标
主要结局
To compare the outcome attenuation of hemodynamic response to pneumoperitonium and post operative analgesia during general anaesthesia in laparoscopic assisted general anaesthesia
时间窗: Parameters like Heart rate,Systolic Blood pressure,Diastolic Blood pressure,Mean arterial Blood pressure and oxygen saturation are will be monitored at Baseline,Before induction,3 mins after Intubation,Before pneumoperitoneum,10 mins after pneumoperitoneum,then at every 30 mins interval till 180 mins.Along with this, above mentioned parameters will also be monitored 10 mins after pneumoperitoneum release and ten mins after extubation.VAS Pain Score will be monitored .
次要结局
- HR,SBP,DBP,MAP ,Spo2,VAS score and complications like bradycardia and hypotension are monitored.(5 hours)