A Clinical trial To compare the effect of dexmedetomidine and clonidine during laproscopic uterus removal operation under general anaesthesia.

Phase 4

Completed

• Conditions: Noninflammatory disorders of female genital tract,

• Registration Number: CTRI/2018/12/016609
• Lead Sponsor: SHANMUGAVALLI E

Brief Summary

Randomized clinical trial to study the effect of intravenous dexmedetomidine and intravenous clonidine on hemodynamic response to pneumoperitoneum during general anaeshesia and post opeative analgesic effect in laparoscopic assisted vaginal hysterectomy.

Detailed Description

Not available

Study Timeline

• Study Start: 2018-12-25
• Last Update Posted: 2022-12-12

Recruitment & Eligibility

• Status: Completed
• Sex: Female
• Target Recruitment: 100

Inclusion Criteria

• ASA Physical status I and II.
• Elective laparoscopic assisted vaginal hysterectomy.

Exclusion Criteria

• ASA physical status III,IV and V.
• Patients with aortic stenosis.
• Patient with history of congestive heart failure,liver disease,renal failure.
• Patients with any degree of atrioventricular block.
• Patients taking beta blocker and monoamine-oxidase inhibitors.

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
To compare the outcome attenuation of hemodynamic response to pneumoperitonium and post operative analgesia during general anaesthesia in laparoscopic assisted general anaesthesia	Parameters like Heart rate,Systolic Blood pressure,Diastolic Blood pressure,Mean arterial Blood pressure and oxygen saturation are will be monitored at Baseline,Before induction,3 mins after Intubation,Before pneumoperitoneum,10 mins after pneumoperitoneum,then at every 30 mins interval till 180 mins.Along with this, above mentioned parameters will also be monitored 10 mins after pneumoperitoneum release and ten mins after extubation.VAS Pain Score will be monitored .

Secondary Outcome Measures

Name	Time	Method
HR,SBP,DBP,MAP ,Spo2,VAS score and complications like bradycardia and hypotension are monitored.	5 hours

Trial Locations

Locations (1)

Velammal medical college hospital and research institute; 🇮🇳 Madurai, TAMIL NADU, India

Velammal medical college hospital and research institute

🇮🇳Madurai, TAMIL NADU, India

DrESHANMUGAVALLI

Principal investigator

9940882722

Vallijegan@gmail.com