Assessment of endothelial function, accumulation of advanced glycation end products and atherosclerosis in patients with longstanding Rheumatoid Arthritis
Completed
- Conditions
- Atherosclerosiscardiovascular disease1002321310003216
- Registration Number
- NL-OMON32391
- Lead Sponsor
- niversitair Medisch Centrum Groningen
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 100
Inclusion Criteria
-Rheumatoide arthritis; American College of Rheumatology criteria for RA
-disease duration of 10-15 year
-informed consent
Exclusion Criteria
Rheumatoid arthritis patients:
-Pregnancy
-Diabetes mellitus (fasting blood glucose * 7.0 mmol/L)
-Renal impairment (serum creatinine *:140 *mol/L)
-Recent Surgery
-Myocardial infarction (MI) or sepsis in the past three months;Healthy age and sex matched controls:
-Pregnancy
-Diabetes mellitus (fasting blood glucose * 7.0 mmol/L)
-Renal impairment (serum creatinine *:140 *mol/L)
-Recent Surgery
-MI or sepsis in the past three months
Study & Design
- Study Type
- Observational invasive
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>Small Artery Elasticity (SAE) en Large Artery Elasticity (LAE) gemeten met PWA.<br /><br>EC Activation Markers (TM, sVCAM-1, vWF, hsCRP), Advanced Glycation<br /><br>Endproducts (AGE), Intima Media Thickness (IMT)</p><br>
- Secondary Outcome Measures
Name Time Method <p>Blood count, ALAT, ASAT, creatinin, cholesterol, triglycerides,<br /><br>HDL-cholesterol, LDL-cholesterol, CRP, blood pressure, pulse rate, BMI,<br /><br>smoking, family history for CVD, RA disease activity and joint destruction<br /><br></p><br>