SAM study: An epigenetic therapy for depression after childhood trauma
- Conditions
- bipolar disorderdepressionDNA methylationchildhood traumaSAMeS-adenosyl-L-methionineepigenetic
- Registration Number
- NL-OMON21753
- Lead Sponsor
- niversity Medical Centre Utrecht
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Pending
- Sex
- Not specified
- Target Recruitment
- 100
Inclusion Criteria
1.Diagnosis of bipolar disorder as defined by DSM-IV-R as determined by the SCID.
2.Age 18 -65 years.
Exclusion Criteria
1.Psychiatric admission in the past six months
2.Compulsory admission or treatment under Dutch law (BOPZ)
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method 50 percent reduction of 50% or more of the Hamilton Depression Rating Scale
- Secondary Outcome Measures
Name Time Method MADRS, genome-wide DNA methylation and KITLG methylation, Altered stress resilience