The Epidemiology of Atopic Dermatitis, Associated Comorbidities, and Treatment Patterns in the United Kingdom (UK)
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 148,166
- 试验地点
- 1
- 主要终点
- Primary Care Referrals
研究概览
简要总结
Atopic dermatitis (AD), commonly called eczema, is one of the most frequently occurring skin conditions. It is estimated to affect around one fifth of children in developed countries and is also becoming increasingly common in less developed countries. Exact estimates of how common eczema is, vary considerably and there has not been an in-depth analysis of the number of people with eczema in the UK. It is also unclear which groups of people are most affected and which treatment options are being used.
Most people with eczema are managed by their general practitioner (GP) with only a few people requiring specialist care. GP records therefore provide an excellent opportunity to explore how common eczema is and which treatments are being used currently.
详细描述
Objective
The study aims to describe the health care resource utilisation of patients with active AD in terms of prescription use, primary care appointments, and specialist referrals.
Method This study will define AD cases using a previously validated algorithm for case identification use clinical codes form primary care in the UK (Read codes). The study will analyse a cohort of prevalent active AD cases over a one year period (2018). The annual use of topical and oral medications used for the treatment of AD, primary care appointments, and specialist referrals will be reported.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 0 Years 至 —（Child, Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •All paediatric and adult patients registered with an Royal College of General Practitioners (RCGP) Research and Surveillance Centre (RSC) contributing GP practice during the study period (2008-2018) and with at least one year of follow-up.
排除标准
- •The presence of psoriasis, photodermatitis, or ichthyosis
结局指标
主要结局
Primary Care Referrals
时间窗: Jan - Dec 2018 inclusive
Annual rate of primary care consultations in 2018
Prescription Rates for Atopic Dermatitis Related Treatments: Topical Antimicrobials
时间窗: Jan - Dec 2018 inclusive
Proportion of the arm/group receiving at least one prescription for topical antimicrobials.
Prescription Rates for Atopic Dermatitis Related Treatments: Emollients and Soap Substitutes
时间窗: Jan - Dec 2018 inclusive
Proportion of the arm/group receiving at least one prescription for emollients and soap substitutes.
Prescription Rates for Atopic Dermatitis Related Treatments: Mild Topical Corticosteroids (TCS)
时间窗: Jan - Dec 2018 inclusive
Proportion of the arm/group receiving at least one prescription for mild topical corticosteroids (atopic dermatitis related treatment)
Prescription Rates for Atopic Dermatitis Related Treatments: Moderate Topical Corticosteroids (TCS)
时间窗: Jan - Dec 2018 inclusive
Proportion of the arm/group receiving at least one prescription for moderate topical corticosteroids (an atopic dermatitis related treatment)
Prescription Rates for Atopic Dermatitis Related Treatments: Potent Topical Corticosteroids (TCS)
时间窗: Jan - Dec 2018 inclusive
Proportion of the arm/group receiving at least one prescription for potent topical corticosteroids (an atopic dermatitis related treatment)
Prescription Rates for Atopic Dermatitis Related Treatments: Very Potent Topical Corticosteroids (TCS)
时间窗: Jan - Dec 2018 inclusive
Proportion of the arm/group receiving at least one prescription for very potent topical corticosteroid (an atopic dermatitis related treatment)
Prescription Rates for Atopic Dermatitis Related Treatments: Topical Calcineurin Inhibitors (TCI)
时间窗: Jan - Dec 2018 inclusive
Proportion of the arm/group receiving at least one prescription for a topical Calcineurin Inhibitor (an atopic dermatitis related treatment)
Specialist Referrals
时间窗: Jan - Dec 2018 inclusive
Specialist dermatology referral rate in 2018
Prescription Rates for Atopic Dermatitis Related Treatments: Antihistamin
时间窗: Jan - Dec 2018 inclusive
Proportion of the arm/group receiving at least one prescription for antihistamin.
Prescription Rates for Atopic Dermatitis Related Treatments: Systemic Immuno-modulatory Therapy
时间窗: Jan - Dec 2018 inclusive
Proportion of the arm/group receiving at least one prescription for Systemic immuno-modulatory therapy
Prescription Rates for Atopic Dermatitis Related Treatments: Oral Corticosteroids
时间窗: Jan - Dec 2018 inclusive
Proportion of the arm/group receiving at least one prescription for oral corticosteroids
次要结局
未报告次要终点