Trends in the Epidemiology and Treatment of Atopic Dermatitis in the United Kingdom (UK)

Completed

Conditions: Atopic Dermatitis
Atopic Dermatitis Eczema
Eczema

Registration Number: NCT03823794

Lead Sponsor: Momentum Data

Brief Summary: Atopic dermatitis (AD), commonly called eczema, is one of the most frequently occurring skin conditions. It is estimated to affect around one fifth of children in developed countries and is also becoming increasingly common in less developed countries. Exact estimates of how common eczema is, vary considerably and there has not been an in-depth analysis of the number of people with eczema in the UK. It is also unclear which groups of people are most affected and which treatment options are being used.

Most people with eczema are managed by their general practitioner (GP) with only a few people requiring specialist care. GP records therefore provide an excellent opportunity to explore how common eczema is and which treatments are being used currently.

Detailed Description: Objective

The study aims to describe the health care resource utilisation of patients with active AD in terms of prescription use, primary care appointments, and specialist referrals.

Method This study will define AD cases using a previously validated algorithm for case identification use clinical codes form primary care in the UK (Read codes). The study will analyse a cohort of prevalent active AD cases over a one year period (2018). The annual use of topical and oral medications used for the treatment of AD, primary care appointments, and specialist referrals will be reported.

Recruitment & Eligibility

Status: COMPLETED

Sex: All

Target Recruitment: 148166

Inclusion Criteria

All paediatric and adult patients registered with an Royal College of General Practitioners (RCGP) Research and Surveillance Centre (RSC) contributing GP practice during the study period (2008-2018) and with at least one year of follow-up.

Exclusion Criteria

The presence of psoriasis, photodermatitis, or ichthyosis

Study & Design

Study Type: OBSERVATIONAL

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Prescription Rates for Atopic Dermatitis Related Treatments: Mild Topical Corticosteroids (TCS)	Jan - Dec 2018 inclusive	Proportion of the arm/group receiving at least one prescription for mild topical corticosteroids (atopic dermatitis related treatment)
Prescription Rates for Atopic Dermatitis Related Treatments: Topical Antimicrobials	Jan - Dec 2018 inclusive	Proportion of the arm/group receiving at least one prescription for topical antimicrobials.
Prescription Rates for Atopic Dermatitis Related Treatments: Emollients and Soap Substitutes	Jan - Dec 2018 inclusive	Proportion of the arm/group receiving at least one prescription for emollients and soap substitutes.
Prescription Rates for Atopic Dermatitis Related Treatments: Moderate Topical Corticosteroids (TCS)	Jan - Dec 2018 inclusive	Proportion of the arm/group receiving at least one prescription for moderate topical corticosteroids (an atopic dermatitis related treatment)
Prescription Rates for Atopic Dermatitis Related Treatments: Potent Topical Corticosteroids (TCS)	Jan - Dec 2018 inclusive	Proportion of the arm/group receiving at least one prescription for potent topical corticosteroids (an atopic dermatitis related treatment)
Prescription Rates for Atopic Dermatitis Related Treatments: Very Potent Topical Corticosteroids (TCS)	Jan - Dec 2018 inclusive	Proportion of the arm/group receiving at least one prescription for very potent topical corticosteroid (an atopic dermatitis related treatment)
Prescription Rates for Atopic Dermatitis Related Treatments: Topical Calcineurin Inhibitors (TCI)	Jan - Dec 2018 inclusive	Proportion of the arm/group receiving at least one prescription for a topical Calcineurin Inhibitor (an atopic dermatitis related treatment)
Specialist Referrals	Jan - Dec 2018 inclusive	Specialist dermatology referral rate in 2018
Prescription Rates for Atopic Dermatitis Related Treatments: Antihistamin	Jan - Dec 2018 inclusive	Proportion of the arm/group receiving at least one prescription for antihistamin.
Prescription Rates for Atopic Dermatitis Related Treatments: Systemic Immuno-modulatory Therapy	Jan - Dec 2018 inclusive	Proportion of the arm/group receiving at least one prescription for Systemic immuno-modulatory therapy
Prescription Rates for Atopic Dermatitis Related Treatments: Oral Corticosteroids	Jan - Dec 2018 inclusive	Proportion of the arm/group receiving at least one prescription for oral corticosteroids
Primary Care Referrals	Jan - Dec 2018 inclusive	Annual rate of primary care consultations in 2018