Evaluation the effecte of coenzyme Q10 in patients with sepsis
Not Applicable
- Conditions
- Sepsis/septic shock.Septic shockR57.2 (Sep
- Registration Number
- IRCT201504051497N4
- Lead Sponsor
- Vice Chancellor for Research,Isfahan University of Medical Sciences
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete
- Sex
- All
- Target Recruitment
- 40
Inclusion Criteria
Critically ill patients with sepsis (proved or suspected infection) plus at least 2 criteria from following conditions:Body temperature >38.3 c or <36 c, Heart rate > 90 beat/min, Respiratory rate >20 breath/min or PaCO2 < 32 mmHg, White blood cells (WBC) > 12000 cell/mm3, or < 4000 cell/mm3, or >10% immature [band]cells, Sudden change of mental status, and Hypoglycemia (blood glucose<120 mg/dl in the absence of diabetes); APACHE II score =15 on admission day; Availability of oral route administration; Consent of the patients or their relatives.
Exclusion criteria:
Pregnancy; End-stage or DNR (Do Not Resuscitate) patients; Patients enrolled in other studies; Coaglupathy (INR>2)
Exclusion Criteria
Not provided
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Changes in biomarkers levels before and after intervention. Timepoint: Day 1, 3 and 7 of admission. Method of measurement: ELIZA Kit.
- Secondary Outcome Measures
Name Time Method Hospital lenght of stay. Timepoint: Until the end of hospital stay. Method of measurement: Day.;Duration of mechanical ventilation. Timepoint: Until extubation. Method of measurement: Day.;Mortality rate. Timepoint: Day 7 and 28. Method of measurement: Day.