Effect of coenzyme Q10 on oxidative and nitrosative stress
Phase 2
- Conditions
- Depression phase of bipolar disorder.Bipolar affective disorder, current episode mild or moderate depression
- Registration Number
- IRCT2016103022965N5
- Lead Sponsor
- Vice Chancellor for research of Hamadan University of Medical Sciences
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete
- Sex
- All
- Target Recruitment
- 74
Inclusion Criteria
patients between 18-65 years old; patients with diagnosed bipolar depression based on DSM-5 and MADRS score equal to or more than 7 exclusion criteria: patients with anxiety disorder not related to bipolar disorder; patients with mixed episodes of depression and manic or hypomanic phase; patients with severe disease; patients who administrated antidepressant agents during 1 month ago; patients who adminsitrated any antioxidant agents or supplements during 1 month ago; patients who did not administrated drug or placebo regularly at least in 80% of study duration; pregnant patients; nursing patients
Exclusion Criteria
Not provided
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method TNF-a. Timepoint: before the intervention, at the 8th week of intervention. Method of measurement: serum level.;Interleukin 6. Timepoint: before the intervention, at the 8th week of intervention. Method of measurement: serum level.;Interleukin 10. Timepoint: before the intervention, at the 8th week of intervention. Method of measurement: serum level.;Total antioxidant capacity. Timepoint: before the intervention, at the 8th week of intervention. Method of measurement: serum level.;Thiol groups. Timepoint: before the intervention, at the 8th week of intervention. Method of measurement: serum level.;Lipid peroxidation. Timepoint: before the intervention, at the 8th week of intervention. Method of measurement: serum level.
- Secondary Outcome Measures
Name Time Method