Role of High Mobility Group Box 1 as a Prognostic Biomarker in Patients Undergoing Off-pump Coronary Artery Bypass Graft
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 255
- 试验地点
- 1
- 主要终点
- Maximum value of HMGB1
研究概览
简要总结
High mobility group 1 (HMGB1) protein is both a nuclear factor and a secreted protein, and has recently been identified as a cytokine mediator of systemic inflammation. HMGB1 is released by inflammatory cells actively, or increased during cell death passively and mediates inflammatory response. It has been reported to have association with the prognosis after acute coronary syndrome, ischemia-reperfusion injury of myocardium, atherosclerosis and heart failure. This study aimed to investigate the relationship of serum levels of HMGB1 and post operative prognosis of patients who had undergone off-pump coronary artery bypass graft.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Only
- 时间视角
- Prospective
入排标准
- 年龄范围
- 20 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patients undergoing off-pump coronary artery bypass graft
排除标准
- •Patients undergoing off-pump coronary artery bypass graft with other simultaneous surgery
- •Patients participating other study
结局指标
主要结局
Maximum value of HMGB1
时间窗: Change from induction of anesthesia to 2hrs after transfer to intensive care unit
Measure the maximum value of HMGB1 in all patients and calculate median value. And device into upper median value group and under median value group and compare frequency of composite morbidity/mortality rate between two groups. composite morbidity/mortality is as follows: 1. Stroke 2. Renal failure 3. Prolonged ventilation more than 24 hours 4. Deep sternal wound infection 5. Reoperation for any reason 6. Mortality during the hospitalization for surgery, even if over 30 days
次要结局
未报告次要终点