The Thrombotic Effects of Yellowstripe Scad (YSS) Compared to Salmon Among Healthy Overweight Subjects: A Randomized Cross Over Trial
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 50
- 主要终点
- Changes in hemostatic status assessed by immunoassay method
研究概览
简要总结
The study aimed to determine the thrombotic effects of YSS compared with salmon among healthy overweight subjects. It hypothesized that YSS may result significant, favorable thrombotic effects and the effects may be similar with salmon.
详细描述
The project was a randomized, two-period, crossover trial with 8-week treatment periods and 8-week washout period. A total of 50 healthy overweight adults were recruited among staff and students in UPM. All the subjects were randomized into two groups. Each group was served with either cooked YSS (~265 g/ day) or salmon (~246 g/day) thrice per week. Blood and urine samples were collected for laboratory assessment.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Prevention
- 盲法
- None
入排标准
- 年龄范围
- 21 Years 至 55 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Malaysian
- •Overweight participants (BMI 23-27.4 kg/m2)
排除标准
- •Regular use of fish oil supplements during the last one month
- •Regular consumption of fish twice or more per week
- •Vegetarian who excluded all meat, fish, and poultry from their diet
- •Diagnosed with cardiovascular disease, haemostasis disorder, inflammatory disease, diabetes mellitus, hypertension, or other significant medical history that may prohibits the participation
- •Receiving warfarin or aspirin treatment, or medication to lower serum lipids, blood pressure, and inflammation
- •Women who are menopause, pregnant or lactating
研究组 & 干预措施
YSS/salmon group
YSS followed by salmon
干预措施: Salmon (Other)
YSS/salmon group
YSS followed by salmon
干预措施: YSS (Other)
Salmon/YSS group
Salmon followed by YSS
干预措施: YSS (Other)
Salmon/YSS group
Salmon followed by YSS
干预措施: Salmon (Other)
结局指标
主要结局
Changes in hemostatic status assessed by immunoassay method
时间窗: 8 weeks
Hemostatic markers including vWF-A2 and CD62b (p-selectin) in pg/mL are evaluated.
次要结局
- Changes in lipid and glucose profiles analysed by medical diagnostic laboratory(8 weeks)
- Changes in renal function analysed by medical diagnostic laboratory(8 weeks)
- Changes in body mass index (BMI)(8 weeks)
- Changes in blood pressure(8 weeks)
- Changes in liver enzymes analysed by medical diagnostic laboratory(8 weeks)
研究者
Dr. Loh Su Peng
Associate Professor
Universiti Putra Malaysia