Observational Study for the Analysis of Associations Between Cardiovascular and Respiratory Diseases in a Cohort of Latin American Adults
试验速览
- 阶段
- 不适用
- 状态
- Enrolling By Invitation
- 入组人数
- 619
- 试验地点
- 1
- 主要终点
- Metabolic syndrome
研究概览
简要总结
Cardiovascular and respiratory diseases are the first and third cause of death, respectively. Cardiovascular risk is known to increase in groups with impaired lung function; however, the mechanisms behind this association are not fully understood. The aim of CaReS is to elucidate the shared pathophysiology of impaired lung function and cardiovascular risk, and to investigate the risk factors associated with them.
The CaReS Cohort Study includes adults (18-80 years old) from Cartagena de Indias, a tropical city on Colombian Caribbean Coast, where recent population admixture settled a three-hybrid genetic structure (European, African and Ameridian ancestry). At baseline, the cohort will generate extensive data on -omics (e.g., genomics, transcriptomics, metabolomics, and epigenomics), socio-economic wellbeing, lifestyle, medical history, cardiometabolic, inflammatory and liver function markers, as well as objective measures of ventilatory and cardiovascular performance.
The cohort will collect data every three years, for a total period of ten years. Prospective risk of cardiovascular disease and chronic obstructive pulmonary disease (COPD) will be investigated, and their risk factors. Throughout the study period, changes in prevalence, and interactions of various risk factors with these changes will also be ascertained.
A predictive risk score for cardiovascular and chronic respiratory disability will be built, using cross-sectional and longitudinal data.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 80 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Native from Colombian Caribbean Coast
排除标准
- •Pregnant women
- •Walking physical disability
- •Cognitive disability
- •Patients under treatment for any type of cancer
- •Clinical record of primary chronic endocrine disease
- •Clinical record of major respiratory tract surgery
结局指标
主要结局
Metabolic syndrome
时间窗: baseline - 10 years (end of follow up)
Pathologic findings for blood pressure, triglycerides, HDLc, serum glucose, and/or enlarged waist circumference (three or more of this criteria found simultaneously)
Atherosclerosis
时间窗: baseline - 10 years (end of follow up)
Carotid atheroma identified by eco-doppler imaging test
Chronic airflow obstruction
时间窗: baseline - 10 years (end of follow up)
Obstruction patterns in post-bronchodilator spirometry.
Acute cardiovascular event
时间窗: 2nd year (first follow up) - 10 years (end of follow up)
Record of acute coronary heart disease, miocardipathy, and ischemic or hemorragic cerebrovascular event.
次要结局
- Chronic Obstructive Pulmonary Disease (COPD)(baseline - 10 years (end of follow up))
- Hypertension(baseline - 10 years (end of follow up))
- Dyslipidemia(baseline - 10 years (end of follow up))
- Type 2 Diabetes Mellitus(baseline - 10 years (end of follow up))
研究者
Gustavo Mora Garcia
Associate professor
Universidad de Cartagena