Effects of testosterone and exercise (TEX) on fitness, physical activity and vascular health in men.

Phase 3

Completed

• Conditions: Fitness; Physical activity; OverweightVascular health; Overweight; Vascular health; Cardiovascular - Diseases of the vasculature and circulation including the lymphatic system; Diet and Nutrition - Obesity

• Registration Number: ACTRN12615000600549
• Lead Sponsor: Dr Bu Yeap

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2015-06-09
• Study Completion: 2018-08-03
• Last Update Posted: 6 February 2023

Recruitment & Eligibility

• Status: Completed
• Sex: Male
• Target Recruitment: 80

Inclusion Criteria

Men aged 50-70 years with waist circumference 95 cm or more. Total cholesterol 7.0 mmol/L or less, or LDL 4.0 mmol/L or less, eGFR 45 ml/min or more, and total testosterone 6-14 nmol/L with normal haematocrit and PSA, and no evidence of significant liver disease. No clinical indication of pituitary, testicular or prostate disease, and office BP 150 mmHg systolic or less and 95 mmHg diastolic or less.

Exclusion Criteria

Cardiovascular disease shown by history of angina, hospitalisation for myocardial infarction, stroke, heart failure or peripheral artery disease, prostate cancer or other major medical comorbidity (eg. renal or lung disease or cancer, transplantation or use of high dose opiate therapy).

Study & Design

• Study Type: Interventional
• Study Design: Not specified