Testosterone therapy as an adjunct to exercise rehabilitation: effects on exercise capacity, inflammatory markers and quality of life in hypogonadal males with chronic heart failure

Completed

• Conditions: Hypogonadal males with chronic heart failure; Circulatory System

• Registration Number: ISRCTN99667121
• Lead Sponsor: Heart Research (UK)

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2006-09-13
• Last Update Posted: 13 January 2015

Recruitment & Eligibility

• Status: Completed
• Sex: Male
• Target Recruitment: 36

Inclusion Criteria

1. Ambulant males
2. Over 18 years
3. Stable chronic heart failure
4. Blood testosterone level of less than 12 nmol/l
5. Symptoms of hypogonadism

Exclusion Criteria

1. Unstable agina
2. Recent acute myocardial infarction
3. Decompensated heart failure
4. Haemodyamically significant valvular heart disease
5. Uncontrolled hypertension
6. Renal insufficiency
7. Urologic disorders
8. Orthopedic/neurologic illness limiting the ability to exercise

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Exercise capacity at the 12 week time point in relation to baseline.

Secondary Outcome Measures

Name	Time	Method
1. Inflammatory markers<br>2. Tests of cardiac and skeletal muscle function<br>3. Indices of psychological health status<br>4. Quality of life