Prevention of opioid-associated constipation in ventilated intensive care patients

Phase 4

• Conditions: Constipation; Oral and Gastrointestinal - Other diseases of the mouth, teeth, oesophagus, digestive system including liver and colon; Anaesthesiology - Pain management

• Registration Number: ACTRN12620000207910
• Lead Sponsor: Dr Eamon Raith

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2020-02-20
• Last Update Posted: 24 February 2020

Recruitment & Eligibility

• Status: ot yet recruiting
• Sex: All
• Target Recruitment: 300

Inclusion Criteria

Age greater than or equal to 18 years.
-Receiving opiates.
-Mechanically ventilated.
-Suitable for or receiving enteral nutrition.
-Likely to stay in the ICU for at least 72h

Exclusion Criteria

-Age <18 years.
-Contraindications to the use of enteral naloxone/oxycodone combination.
-Have a colostomy
-Bowel obstruction

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Time to first bowel motion.<br><br>This will be assessed as time from enrolment in the trial to first bowel motion. Bowel opening is recorded on the ICU chart by nursing staff. A form will be present with the nursing staff in order to record specific times of bowel opening.[Time to first bowel motion will be assessed hourly for 7 days until the first bowel movement occurs. Specific time that a bowel motion is noted will be recorded on a specific form kept at the ICU Nurse's station at the patient bedside.]