Cognitive Rehabilitation for Individuals With Parkinson's Disease and MCI
Overview
- Phase
- N/A
- Intervention
- Not specified
- Conditions
- Parkinson's Disease
- Sponsor
- VA Office of Research and Development
- Enrollment
- 110
- Locations
- 1
- Primary Endpoint
- Wechsler Adult Intelligence Scale-IV (WAIS-IV) Matrix Reasoning Test Total Scaled Score
- Status
- Completed
- Last Updated
- 5 years ago
Overview
Brief Summary
To investigate the effectiveness of a novel compensatory cognitive rehabilitation program for individuals with Parkinson's disease (PD) and mild cognitive impairment (MCI).
Detailed Description
Eligible study participants will be randomly assigned to one of two interventions: 1) Cognitive Rehabilitation (Cognitive Symptom Management and Rehabilitation Therapy for Parkinson's disease; CogSMART-PD) or 2) Supportive Care. Interventions are held within a group format consisting of approximately 5 individuals with PD. Groups will meet once per week for 1.5 hours over a 10-week period. Neuropsychological testing will be administered pre- and post-intervention as well as 6- and 12-months after the intervention.
Investigators
Eligibility Criteria
Inclusion Criteria
- •Diagnosis of Parkinson's disease
- •Mild Cognitive Impairment
- •Over 40 years of age
- •Fluent English speaker
Exclusion Criteria
- •Other neurological conditions (e.g., stroke) besides Parkinson's disease
Outcomes
Primary Outcomes
Wechsler Adult Intelligence Scale-IV (WAIS-IV) Matrix Reasoning Test Total Scaled Score
Time Frame: Baseline and Week 10
The WAIS-IV Matrix Reasoning test is a validated, objective measure of executive function. Scaled scores range from 0 to 26. Higher scores indicate better executive function. Scores reported below are change scores.
Secondary Outcomes
- Cognitive Problems and Strategies Assessment (CPSA) Memory Strategies Use Score(Baseline and Week 10)
- Informant Questionnaire on Cognitive Decline in the Elderly (IQCODE) Total Score(Baseline and Week 10)
- Memory for Intention Test (MIST) Total Score(Baseline and Week 10)
- World Health Organization Quality of Life (WHOQOL)-BREF Psychological Domain Transformed Score(Baseline and Week 10)
- Delis-Kaplan Executive Functioning System (D-KEFS): 20 Questions Test Total Questions Asked Scaled Score(Baseline and Week 10)
- Parkinson's Disease Questionnaire-39 (PDQ-39) Total Score(Baseline and Week 10)
- Neuropsychiatric Inventory-Questionnaire (NPI-Q) Total Month Score(Baseline and Week 10)
- Informant Questionnaire on Cognitive Decline in the Elderly-Self Report (IQCODE-SR) Total Score(Baseline and Week 10)