Cognitive Rehabilitation for Individuals With Parkinson's Disease and MCI
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 110
- 试验地点
- 2
- 主要终点
- Wechsler Adult Intelligence Scale-IV (WAIS-IV) Matrix Reasoning Test Total Scaled Score
研究概览
简要总结
To investigate the effectiveness of a novel compensatory cognitive rehabilitation program for individuals with Parkinson's disease (PD) and mild cognitive impairment (MCI).
详细描述
Eligible study participants will be randomly assigned to one of two interventions: 1) Cognitive Rehabilitation (Cognitive Symptom Management and Rehabilitation Therapy for Parkinson's disease; CogSMART-PD) or 2) Supportive Care. Interventions are held within a group format consisting of approximately 5 individuals with PD. Groups will meet once per week for 1.5 hours over a 10-week period. Neuropsychological testing will be administered pre- and post-intervention as well as 6- and 12-months after the intervention.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Double (Investigator, Outcomes Assessor)
盲法说明
Investigator and Assessor are blinded to group assignment.
入排标准
- 年龄范围
- 40 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Diagnosis of Parkinson's disease
- •Mild Cognitive Impairment
- •Over 40 years of age
- •Fluent English speaker
排除标准
- •Other neurological conditions (e.g., stroke) besides Parkinson's disease
结局指标
主要结局
Wechsler Adult Intelligence Scale-IV (WAIS-IV) Matrix Reasoning Test Total Scaled Score
时间窗: Baseline and Week 10
The WAIS-IV Matrix Reasoning test is a validated, objective measure of executive function. Scaled scores range from 0 to 26. Higher scores indicate better executive function. Scores reported below are change scores.
次要结局
- Cognitive Problems and Strategies Assessment (CPSA) Memory Strategies Use Score(Baseline and Week 10)
- Informant Questionnaire on Cognitive Decline in the Elderly (IQCODE) Total Score(Baseline and Week 10)
- Memory for Intention Test (MIST) Total Score(Baseline and Week 10)
- World Health Organization Quality of Life (WHOQOL)-BREF Psychological Domain Transformed Score(Baseline and Week 10)
- Delis-Kaplan Executive Functioning System (D-KEFS): 20 Questions Test Total Questions Asked Scaled Score(Baseline and Week 10)
- Parkinson's Disease Questionnaire-39 (PDQ-39) Total Score(Baseline and Week 10)
- Neuropsychiatric Inventory-Questionnaire (NPI-Q) Total Month Score(Baseline and Week 10)
- Informant Questionnaire on Cognitive Decline in the Elderly-Self Report (IQCODE-SR) Total Score(Baseline and Week 10)