Resynchronisation Therapy of Right Ventricle in Pulmonary Arterial Hypertension
试验速览
- 阶段
- 不适用
- 入组人数
- 15
- 试验地点
- 2
- 主要终点
- cardiac index measured during right catheterization
研究概览
简要总结
Pulmonary arterial hypertension is a disease characterised by pathological changes in the pulmonary arteries leading to a progressive increase in pulmonary vascular resistance and pulmonary artery pressure. Right ventricular failure is the main cause of death in patients with pulmonary arterial hypertension, and the ability of the right ventricle to adapt to the progressive increase in pulmonary vascular resistance associated with changes to the pulmonary vasculature in pulmonary arterial hypertension is the main determinant of a patient's functional capacity and survival.
Right ventricular dyssynchrony was present in a substantial proportion of patients with pulmonary arterial hypertension and this dyssynchrony adversely affected right ventricular function.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Pulmonary hypertension type I, III, IV, V Dana Point classification
- •NYHA classification equal or superior to stage II
- •During right catetherization : cardiac index inferior or equal 2.5 L/mn/m2 and atrial pressure superior or equal 10 mmHg OR cardiac index equal or inferior to 2.2 L/mn/m2
- •Optimal therapy considered by the referring specialist practioner of the patient
排除标准
- •Minor or incapacitated adult
- •Pregnancy
- •Unability to give free and informed consent
- •Pulmonary hypertension type II Dana Point classification
- •Eisenmenger syndrome
- •Patent foramen ovale
- •Left bundle-brach block
- •Pulmonary hypertension exacerbation
- •Medical clinical situation considered inappropriate by the investigator
- •Patient eligible for a heart-lung transplant
- •Patient eligible for pulmonary endarterectomy
- •Patient with poor echogenicity
- •Filter in the inferior vena cava
结局指标
主要结局
cardiac index measured during right catheterization
时间窗: After two minutes of right stimulation
次要结局
未报告次要终点