Right Ventricular Geometry, Function, Morphology and Pulmonary Arterial Stiffness and Size Evaluation by Cardiac Magnetic Resonance
试验速览
- 阶段
- 不适用
- 入组人数
- 100
- 试验地点
- 1
- 主要终点
- Right ventricle mechanical changes in pulmonary hypertension patients during follow up
研究概览
简要总结
Pulmonary hypertension results in right ventricle dysfunction. Cardiac magnetic resonance derived RV ejection fraction is a prognostic value in this condition.
Right ventricular geometry, function, morphology as well as pulmonary arterial stiffness and size may be evaluated by cardiac magnetic resonance imaging and could have great importance in evaluation of pulmonary hypertension prognosis and outcomes.
详细描述
Pulmonary hypertension is defined as an increase in mean pulmonary artery pressure > 25 mmHg evaluated by right heart catheterisation. Over time increased pulmonary artery pressure eventually causes vascular remodelling and right ventricular dysfunction. The right and left ventricles interact sharing a common pericardial sac and interventricular septum. Frequently right ventricle dysfunction reflects clinical PH worsening.
The aim of this study was to assess the geometry, function and morphology of right ventricle and also pulmonary artery diameter and stiffness in pulmonary hypertension patients by cardiovascular magnetic resonance.
Patients are recruited from the Hospital of Lithuanian University of Health Sciences Kaunas clinics Pulmonary hypertension center.
Study inclusion criteria:
- Patient with diagnosed pulmonary hypertension
- RHC, 6MWT, echocardiography, NT-pro BNP, CMR performed in one month period.
- Patients who signed study informed consent form.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Only
- 时间视角
- Prospective
入排标准
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patient with diagnosed pulmonary hypertension
- •RHC, 6MWT, echocardiography, NT-pro BNP, CMR performed in one month period.
- •Patients who signed study informed consent form.
排除标准
- •Coronary and valvular heart disease
- •Atrial fibrillation
- •Expressed shortness of breath
- •Claustrophobia.
结局指标
主要结局
Right ventricle mechanical changes in pulmonary hypertension patients during follow up
时间窗: 2 years
Right ventricle function and mechanical changes will be evaluated by FT at base line and during follow up to find significant values for disease progression and prognosis
Left ventricle function and mechanical changes in pulmonary hypertension patients during follow up
时间窗: 2 years
Left ventricle function and mechanical changes will be evaluated by CMR and FT at base line and during follow up to find significant values for disease progression and prognosis
Right ventricle function and morphological changes in pulmonary hypertension patients during follow up
时间窗: 2 years
Pulmonary artery will be evaluated by CMR at base line and during follow up to find significant values for disease progression and prognosis
次要结局
未报告次要终点
研究者
Egle Ereminiene
Clinical Professor
Lithuanian University of Health Sciences