Effects of mannitol and hypertonic saline on cerebral oxygenation and metabolism in patients with posttraumatic intracranial hypertension.
- Conditions
- brain swellingintracranial hypertension10021666
- Registration Number
- NL-OMON30018
- Lead Sponsor
- niversitair Medisch Centrum Sint Radboud
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Pending
- Sex
- Not specified
- Target Recruitment
- 32
Inclusion Criteria
Adult patients
Severe traumatic brain injury (Glasgow Coma Scale at first presentation < 9)
Intracranial hypertension (intracranial pressure > 20 mm Hg)
Exclusion Criteria
No informed consent from the patient*s legal representative.
Expected survival < 2 days
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>The primary endpoint of the study will be cerebral oxygenation as measured by<br /><br>intracerebral PO2 (expressed as mmHg). </p><br>
- Secondary Outcome Measures
Name Time Method <p>Secondary endpoints will be cerebral blood flow, metabolism and inflammation.<br /><br>Cerebral blood flow will be measured by transcranial Doppler and expressed as<br /><br>flow in cm/sec. The balance between aerobic and anaerobic metabolism will be<br /><br>determined by measuring intraparenchymal lactate/pyruvate ratio using cerebral<br /><br>microdialysis. Components of the inflammatory response such as the pro- and<br /><br>anti-inflammatory cytokines IL-6, TNF-a and IL-10 will be measured in blood<br /><br>from the jugular bulb.</p><br>