Correlation Between Angle Closure Glaucoma Data and Lens Zonule Status

Completed

• Conditions: Primary Angle Closure Glaucoma

• Registration Number: NCT06184620
• Lead Sponsor: Guangfu Dang

Brief Summary

The goal of this observational study is to discuss the correlation between primary angle-closure glaucoma and the state of the suspended ligament of the lens and the pathogenesis of PACG by measuring the biological data of primary angle-closure glaucoma and observing its anatomical changes.

Detailed Description

Patients clinically diagnosed with Primary angle-closure glaucoma (PACG) and normal control patients from December 2020 to January 2022 were enrolled in this study.

Study Timeline

• Study Start: 2020-12-01
• Primary Completion: 2023-03-30
• Study Completion: 2023-03-30
• Status Verified: 2023-12
• Study First Submitted: 2023-12-14
• Study First Submitted QC: 2023-12-14
• Last Update Submitted: 2023-12-14
• Study First Posted: 2023-12-28
• Last Update Posted: 2023-12-28

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 263

Inclusion Criteria

• The depth of the anterior chamber is normal, and the whole corner of the chamber is open;
• The cup-to-plate ratio is less than 0.5;
• No family history of glaucoma.

Exclusion Criteria

• Previous history of trauma or internal eye surgery in both eyes or one eye;
• Used "pilocarpine", "atropine" and other drugs to change the size of the pupil and the shape of the chamber Angle within 1 week;
• Combined with other eye diseases affecting the Angle and suspension ligament, such as uveitis, ciliary cyst, high myopia, retinal diseases, etc.;
• Can not cooperate with UBM and Angle scopy;
• Refuse to participate in this researcher.

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Axial Length (AL), Lens Thickness (LT),Lens Vault (LV), Pupil Diameter (PD),	before operation	Axial Length (AL), Lens Thickness (LT),Lens Vault (LV), Pupil Diameter (PD),
Anterior Chamber Depth (ACD) in seat and rectum position, White To White (WTW), pupil vault (LV), pupil diameter (PD), The Lens Zonular Length (LZL) and Angle Opening Distance at 500μm (AOD500) in the upper, lower, nasal and temporal directions	before operation	Anterior Chamber Depth (ACD) in seat and rectum position, White To White (WTW), pupil vault (LV), pupil diameter (PD), The Lens Zonular Length (LZL) and Angle Opening Distance at 500μm (AOD500) in the upper, lower, nasal and temporal directions

Trial Locations

Locations (1)

guangfu Dang; 🇨🇳 Jinan, Shandong, China