The role of serum microRNAs and inflammatory mediators in intervertebral disc degeneration and their value as biomarkers
Not Applicable
- Conditions
- Health Condition 1: M472- Other spondylosis with radiculopathy
- Registration Number
- CTRI/2021/04/032570
- Lead Sponsor
- Yenepoya University Deemed to be
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- ot Yet Recruiting
- Sex
- Not specified
- Target Recruitment
- 0
Inclusion Criteria
All patients with low backache and who have undergone MRI for the evaluation of backache, which confirms the presence of disc degeneration of the lumbar spine.
Exclusion Criteria
Patients with a history of previous trauma or infections to the spine.
Diabetes mellitus, patients with inflammatory arthritis. Patients who have undergone previous surgery.
Patients who have major deformities like scoliosis and kyphosis.
Study & Design
- Study Type
- Observational
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method 1. List of miRNAs and serum proteins from disc material and blood. <br/ ><br>2. Correlation of these miRNA and serum proteins between different age groups, and different grades of disc degeneration.Timepoint: 0 (Baseline)
- Secondary Outcome Measures
Name Time Method Validation of miRNA and serum biomarkers using literature.Timepoint: 0-2 years