comparison of Adaptive Support Ventilation (ASV) and Synchronized Intermittent Mandatory Ventilation (SIMV) modes
Phase 3
- Conditions
- mechanical ventilation.Other specified medical care
- Registration Number
- IRCT2015112016151N3
- Lead Sponsor
- Vice chancellor of research of Iran University of Medical Sciences
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete
- Sex
- All
- Target Recruitment
- 54
Inclusion Criteria
hospitalized in neurosurgery ICU; decreased consciousness; need to intubation and mechanical ventilation; no respiratory failure. Exclusion criteria: severe liver failure (ascites, abnormal liver function tests); severe liver and renal failure ; severe lung disease based on PFT (FEV1<50%); confirmed obstructive lung diseases (asthma, emphysema, chronic bronchitis, small airway disease); bronchiectasis; confirmed restrictive lung diseases (fibrosis of lungs); heart failure (EF<45%); obesity (BMI>30); pregnancy; smoking; respiratory failure (MAP<60 mm/Hg, T>38, PH<7.3, PCO2>50, PO2<60 with FiO2<0.6); involvement or lesion of brain stem.
Exclusion Criteria
Not provided
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Peak airway pressure. Timepoint: minutes 10,20,30. Method of measurement: cm H2O by ventilator.;Static lung compliance. Timepoint: 30 minutes after intervention. Method of measurement: ml/cm H20 by ventilator.;Dynamic lung compliance. Timepoint: 30 minutes after intervention. Method of measurement: ml/cm H20 by ventilator.
- Secondary Outcome Measures
Name Time Method Arterial CO2. Timepoint: minutes 10,20,30. Method of measurement: mmHg by ABG.;Arterial oxygen presuure. Timepoint: minutes 10,20,30. Method of measurement: mmHg by ABG.;Respiratory rate. Timepoint: minutes 10,20,30. Method of measurement: rate in minute.