临床试验/NCT04383431

NCT04383431已完成不适用

Standard Cross-linking Versus Accelerated Photoactivated Chromophore Cross-linking (PACK-CXL) for Treatment of Infectious Keratitis: A Comparative Study

Sohag University2 个研究点分布在 1 个国家目标入组 37 人开始时间: 2020年6月2日最近更新: 2023年1月18日

适应症

试验速览

阶段: 不适用
状态: 已完成
发起方: Sohag University
入组人数: 37
试验地点: 2
主要终点: Corneal healing

研究概览研究设计入排标准结局指标研究者研究点记录与标识符相似试验

研究概览

简要总结

To compare between SCXL and ACXL for treatment of infectious keratitis

详细描述

Standard epithelium-off CXL, 30 minutes soaking time with riboflavin, 30 minutes UVA corneal irradiation continuous mode (Group A). Accelerated CXL 11 minutes soaking time with riboflavin, 8 minutes UVA corneal irradiation pulsed mode (Group B).

研究设计

研究类型: Interventional
分配方式: Randomized
干预模型: Parallel
主要目的: Treatment
盲法: None

入排标准

性别: All
接受健康志愿者: 否

入选标准

•Fungal infectious keratitis
•bacterial infectious keratitis
•Must be not responding to medication

排除标准

•Viral keratitis
•Pregnancy and lactation

结局指标

主要结局

Corneal healing

时间窗: 3 months

Reepithelization of corneal ulcer which is measured in mm by slitlamp examination

Corneal edema

时间窗: 3 months

measurement of corneal edema by measurement of the corneal thickness in um by Optical Coherent Tomography

次要结局

未报告次要终点

研究者

发起方

Sohag University

申办方类型

Other

责任方

Principal Investigator

主要研究者

Prof. Mohammed Iqbal

Assistant Professor of Ophthalmology

Sohag University

研究点 (2)

Loading locations...

相似试验

已完成

不适用

Accelerated Versus Standard CXL in the Treatment of Ectasia Post Refractive Surgery and Penetrating Keratoplasty.Refractive Surgery

NCT03791684Menoufia University111

招募中

2 期

Comparison of Standard vs. Accelerated Corneal CrosslinkingEctasia CornealKeratoconus

NCT03922542Price Vision Group510

Unknown

1 期

Clinical and Structural Outcome of Conventional Versus Accelerated Corneal Collagen Cross-linking (CXL).Corneal EctasiaKeratoconus

NCT02883478Oslo University Hospital40

已完成

3 期

Swiss PACK-CXL Multicenter Trial for the Treatment of Infectious KeratitisKeratitis; Infectious Disease (Manifestation)

NCT02717871University Hospital, Geneva35

已完成

不适用

Corneal Collagen Cross-linking (CXL) versus Combined CXL and Femtosecond Laser-assisted Intra-corneal Ring Segment Implantation for Treatment of Keratoconus

PACTR202102825518454Faculty of Medicine university of Alexandria60