General Anesthetics-related Changes in Prefrontal EEG During Pediatric Surgical Anesthesia
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 入组人数
- 366
- 试验地点
- 1
- 主要终点
- bicoherence
研究概览
简要总结
The change profiles of indices derived from pEEG such as phase-amplitude coupling and bicoherence based on individual general anesthetics in children have not been examined in previous literature. Whether those indices have the abilities to predict individual drug-related anesthesia depth in children need to be explored.
详细描述
The need to maintain a proper depth of general anesthesia during pediatric surgery is an important aspect of anesthesiology. An inappropriate anesthesia depth increases the risk of intraoperative awareness or delay in recovery in children undergoing surgery. Current modalities for anesthesia depth monitoring showed limited accuracy in children. The electroencephalogram (EEG) can be analyzed in its raw form for characteristic drug-induced patterns of change or summarized using mathematical parameters as a processed electroencephalogram (pEEG). The change profiles of indices derived from pEEG such as phase-amplitude coupling and bicoherence based on individual general anesthetics in children have not been examined in previous literature. Whether those indices have the abilities to predict individual drug-related anesthesia depth in children need to be explored.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 1 Minute 至 18 Years（Child, Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •patients aged 0-18 years, American Society of Anesthesiologists Physical Status I-II, scheduled for elective surgery in Peking University First Hospital.
排除标准
- •Preterm patients;
- •Height and weight not within the standard ranges for respective ages;
- •Surgery for head or heart;
- •Patients with muscular, neurologic or psychiatric diseases;
- •Patients with Congenital anomaly or hereditary diseases;
- •Patients with medication abuse;
- •Allergy to medication including propofol, sevoflurane, and ketamine;
- •Allergy to beans;
- •Refusal to participate the study by guardians.
研究组 & 干预措施
propofol
General anesthesia is induced and maintained mainly with propofol.
干预措施: propofol (Drug)
sevoflurane
General anesthesia is induced and maintained mainly with sevoflurane.
干预措施: sevoflurane (Drug)
ketamine
General anesthesia is induced mainly with S-ketamine and maintained mainly with propofol.
干预措施: S-ketamine (Drug)
结局指标
主要结局
bicoherence
时间窗: induction and maintenance, and recovery of anesthesia
bicoherence
phase-amplitude coupling
时间窗: induction, maintenance, and recovery of anesthesia
phase-amplitude coupling
spectral analysis
时间窗: induction and maintenance, and recovery of anesthesia
spectral analysis
entropy indices
时间窗: induction and maintenance, and recovery of anesthesia
entropy indices
次要结局
未报告次要终点
研究者
Dong-Xin Wang
Professor
Peking University First Hospital