Characteristic Changes During Anesthesia With Etomidate and Propofol

Air Force Military Medical University, China1 site in 1 country68 target enrollmentFebruary 28, 2022

ConditionsGeneral Anesthesia

Interventionsetomidate anesthesia propofol anesthesia

Drugsetomidate anesthesia propofol anesthesia

Overview

Phase: N/A
Intervention: etomidate anesthesia
Conditions: General Anesthesia
Sponsor: Air Force Military Medical University, China
Enrollment: 68
Locations: 1
Primary Endpoint: delta wave deficiency during anesthesia
Last Updated: 3 years ago

Overview Investigators Eligibility Criteria Arms & Interventions Outcomes Sites Similar Trials

Overview

Brief Summary

Electroencephalography (EEG) monitoring reflect the brain electro-activity. Different anesthetics may show different changes in EEG during anesthesia. Etomidate and propofol are widely used for general anesthesia. The characteristic changes of these two anesthetics may be different.

Registry

clinicaltrials.gov

Start Date

February 28, 2022

End Date

February 28, 2023

Last Updated

3 years ago

Study Type

Interventional

Study Design

Parallel

Sex

All

Investigators

Sponsor

Air Force Military Medical University, China

Responsible Party

Principal Investigator

Zhihong LU

Professor

Air Force Military Medical University, China

Eligibility Criteria

Inclusion Criteria

•Patients scheduled for surgery under general anesthesia
•Patients provided written informed consent

Exclusion Criteria

•Patients with history of neurological or psychiatric diseases
•Patients younger than 18 years old
•Patients scheduled for surgery involved head
•Patients with pregnancy or planned for breeding

Arms & Interventions

etomidate

Intervention: etomidate anesthesia

propofol

Intervention: propofol anesthesia

Outcomes

Primary Outcomes

delta wave deficiency during anesthesia

Time Frame: from anesthesia induction to extubation of the endotracheal tube, on an average of 2.5 hours

Secondary Outcomes

spindle wave deficiency during anesthesia(from anesthesia induction to extubation of the endotracheal tube, on an average of 2.5 hours)
burst suppression during anesthesia(from anesthesia induction to extubation of the endotracheal tube, on an average of 2.5 hours)