Build-up of Action Representation During Neurodevelopment: Dysfunctions in Autism Spectrum Disorders?
Trial Snapshot
- Phase
- Not Applicable
- Status
- Completed
- Sponsor
- Hospices Civils de Lyon
- Enrollment
- 54
- Locations
- 1
- Primary Endpoint
- Changes of cerebral oscillations in three frequency bands (alpha, beta, gamma) during sensori-motor learning.
Study Overview
Brief Summary
Autistic spectrum disorders (ASD) are highly debilitating developmental syndromes which core feature is social and communications disorders. Motor skill impairments are frequently described in autism, but few studies have addressed the question of their origin and their specificity. Furthermore, it is not clear whether motor problems encountered in autism are related to dyspraxia, or if they present with specific features. This project aims at deciphering the origin of motor problems encountered by children who grow-up with autism in order to propose early interventions that could influence the other developmental trajectories, such as the social one.
Brain dynamics during sensori-motor learning is explored by applying magnetoencephalography (MEG) during the Bimanual Load-Lifting paradigm. Different motor processes namely: proprioceptive monitoring, use and update of a sensori-motor representation, anticipatory executive control will be correlated to brain oscillation modulation, both topographically and temporally. Two groups of children (aged between 7 and 12) are compared: a group of children with ASD and a control group of typically developing children.
Study Design
- Study Type
- Interventional
- Allocation
- Non Randomized
- Intervention Model
- Parallel
- Primary Purpose
- Basic Science
- Masking
- None
Eligibility Criteria
- Ages
- 7 Years to 12 Years (Child)
- Sex
- All
- Accepts Healthy Volunteers
- Yes
Inclusion Criteria
- •Control group: children aged between 7 and 12
- •Case group: children aged between 7 and 12 with a diagnostic of Autism Spectrum Disorders
Exclusion Criteria
- •Control group: presence of a neurological pathology, mental retardation or language and motor developmental delay
- •Case group: presence of a neurological pathology, mental retardation
Arms & Interventions
Control group
Children with a typical development.
Intervention: Behavioral assessments (Other)
Control group
Children with a typical development.
Intervention: Magnetoencephalography (MEG) (Other)
Control group
Children with a typical development.
Intervention: Magnetic Resonance Imaging (MRI) (Other)
Case group
Children with Autism Spectrum Disorders.
Intervention: Behavioral assessments (Other)
Case group
Children with Autism Spectrum Disorders.
Intervention: Magnetoencephalography (MEG) (Other)
Case group
Children with Autism Spectrum Disorders.
Intervention: Magnetic Resonance Imaging (MRI) (Other)
Outcomes
Primary Outcomes
Changes of cerebral oscillations in three frequency bands (alpha, beta, gamma) during sensori-motor learning.
Time Frame: Day 1
Oscillatory measures are computed in the sensor and source space in order to identify the regions involved in the sensori-motor learning in the control group and in the ASD group.
Secondary Outcomes
- Correlation between oscillatory measures and learning performance.(Day 1)