Build-up of Action Representation in Autism Spectrum Disorders

Not Applicable

Completed

• Conditions: Autism Spectrum Disorder; Healthy
• Interventions: Other: Behavioral assessments; Other: Magnetoencephalography (MEG); Other: Magnetic Resonance Imaging (MRI)

• Registration Number: NCT03108976
• Lead Sponsor: Hospices Civils de Lyon

Brief Summary

Autistic spectrum disorders (ASD) are highly debilitating developmental syndromes which core feature is social and communications disorders. Motor skill impairments are frequently described in autism, but few studies have addressed the question of their origin and their specificity. Furthermore, it is not clear whether motor problems encountered in autism are related to dyspraxia, or if they present with specific features. This project aims at deciphering the origin of motor problems encountered by children who grow-up with autism in order to propose early interventions that could influence the other developmental trajectories, such as the social one.

Brain dynamics during sensori-motor learning is explored by applying magnetoencephalography (MEG) during the Bimanual Load-Lifting paradigm. Different motor processes namely: proprioceptive monitoring, use and update of a sensori-motor representation, anticipatory executive control will be correlated to brain oscillation modulation, both topographically and temporally. Two groups of children (aged between 7 and 12) are compared: a group of children with ASD and a control group of typically developing children.

Detailed Description

Not available

Study Timeline

• Study Start: 2015-04-10
• Study First Submitted: 2017-03-30
• Study First Submitted QC: 2017-04-05
• Study First Posted: 2017-04-11
• Primary Completion: 2018-12-31
• Study Completion: 2018-12-31
• Status Verified: 2022-08
• Last Update Submitted: 2022-08-25
• Last Update Posted: 2022-08-26

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 54

Inclusion Criteria

• Control group: children aged between 7 and 12
• Case group: children aged between 7 and 12 with a diagnostic of Autism Spectrum Disorders

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Exclusion Criteria

• Control group: presence of a neurological pathology, mental retardation or language and motor developmental delay
• Case group: presence of a neurological pathology, mental retardation

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Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Control group	Magnetic Resonance Imaging (MRI)	Children with a typical development.
Case group	Magnetoencephalography (MEG)	Children with Autism Spectrum Disorders.
Case group	Magnetic Resonance Imaging (MRI)	Children with Autism Spectrum Disorders.
Case group	Behavioral assessments	Children with Autism Spectrum Disorders.
Control group	Behavioral assessments	Children with a typical development.
Control group	Magnetoencephalography (MEG)	Children with a typical development.

Primary Outcome Measures

Name	Time	Method
Changes of cerebral oscillations in three frequency bands (alpha, beta, gamma) during sensori-motor learning.	Day 1	Oscillatory measures are computed in the sensor and source space in order to identify the regions involved in the sensori-motor learning in the control group and in the ASD group.

Secondary Outcome Measures

Name	Time	Method
Correlation between oscillatory measures and learning performance.	Day 1	Kinematic recordings enable to measure the learning performance at the end of the experiment. This measure will be correlated with oscillatory changes during the task.

Trial Locations

Locations (1)

CH le Vinatier; 🇫🇷 Bron, France