Effect of Low-Level Laser on Crevicular Interleukin-1β Concentration in Patients with Periodontal Disease: a Relation to Periodontal Inflammaging

Not Applicable

Completed

• Conditions: Periodontal Diseases; Old Age

• Registration Number: NCT06677385
• Lead Sponsor: Misr University for Science and Technology

Brief Summary

This study is done to compare between young age and old age patients with periodontitis (inflammaging) and the effect of diode laser as adjunctive to scaling and debridement

Detailed Description

Not available

Study Timeline

• Study Start: 2023-07-12
• Primary Completion: 2024-03-12
• Study Completion: 2024-10-12
• Status Verified: 2024-11
• Study First Submitted: 2024-11-04
• Study First Submitted QC: 2024-11-05
• Study First Posted: 2024-11-06
• Last Update Submitted: 2025-02-24
• Last Update Posted: 2025-02-26

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 28

Inclusion Criteria

1. Male or Female

2. Aged below 40 or above 60.

3. Provide informed consent and willingness to cooperate with study protocol.

4. Periodontitis stage II patients:

   • CAL from 3-4 mm.
   • Radiographic bone loss (15% to 33%).
   • No tooth loss due to periodontitis.
   • Maximum probing depth ≤ 5 mm, mostly horizontal bone loss

Exclusion Criteria

1. Patients with heavy smoking habits
2. History of antibiotics in the previous three months.
3. Pregnant or lactating female.
4. Treatment with any systemic drug.
5. History of systemic disease.
6. Patients who received periodontal treatment in the last 6 months

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Primary Outcome Measures

Name	Time	Method
Gingival index	first visit, second follow up after 1 month and final follow up after 6 months
Clinical attachment loss	first visit, second follow up after 1 month and final follow up after 6 months
Interleukin 1 beta	first visit, second follow up after 1 month and final follow up after 6 months	collected and analyzed by ELISA from Gingival crevicular fluid and blood serum

Trial Locations

Locations (1)

Misr University foe Science and Technology; 🇪🇬 Giza, Egypt