Anterior segment OCT for diagnosing early-onset childhood glaucoma

Not yet recruiting

Conditions: Other glaucoma,

Registration Number: CTRI/2025/06/089855

Lead Sponsor: Medical Education Cell Postgraduate Institute of Medical Education and Research Chandigarh

Brief Summary: It will be an observational prospective study including children of 1 day to 5 years of age.

2 groups will be formed . **Group 1** will include children 1 day to 5 years of age diagnosed with non acquired childhood glaucoma as per the CGRN criteria will be considered as **cases**

**Group 2**will include the age matched control of children diagnosed with CNLDO other eye of amblyopic patient other eye of squint patient will be considered as**controls**

- SS ASOCT will be performed in children fulfilling the inclusion criteria in both the groups as a part of routine ophthalmic examination i**n office non invasive** procedure **without any sedation** using flying baby technique

- Visibility of trabecular meshwork TM will be graded as Grade 1 for TM visible Grade 2 for indeterminate TM Grade 3 for TM not visible

- **Grade 1**will be considered as**non glaucomatous**children **Grade 2 and 3**TM will be considered as **glaucomatous**

- Anterior chamber angle ACA parameters like AOD ARA will be compared between glaucomatous children and age matched controls.

- Examination under anesthesia EUA will be done for cases only to make a definitive diagnosis of glaucoma

- Comparison of Sensitivity Specificity Positive Predictive value of SS ASOCT in comparison to standard EUA to diagnose childhood glaucoma based on visibility of trabecular meshwork.

This study will assess the utility of SS ASOCT as an in office non invasive non sedating diagnostic imaging modality to diagnose early childhood glaucoma from normal children.

Detailed Description: Not available

Recruitment & Eligibility

Status: Not Yet Recruiting

Sex: All

Target Recruitment: 30

Inclusion Criteria

CASES: 1 day.
5 years of non acquired childhood Glaucoma as per CGRN classification CONTROLS: Age matched controls with NLDO Age matched controls with emmetropic eye of strabismic patient Age matched control of normal eye of strabismic patient.

Exclusion Criteria

CASES: Children with secondary Glaucoma Children with ocular trauma Children with previous history of any ocular surgery CONTROLS: Children with ocular trauma Children with previous history of any ocular surgery Children with retinal pathologies.

Study & Design

Study Type: Observational

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Diagnosing Childhood Glaucoma based on the appearance of Trabecular Meshwork visibility on SS ASOCT captured in office without any sedation compared to standard examination under anesthesia	8 week \| At the time of EUA to assess the anterior chamber parameters on ASOCT when the definitive diagnosis of glaucoma is made, and then compare it to non-glaucomatous children

Secondary Outcome Measures

Name	Time	Method
Comparison of Anterior Chamber Angle parameters Angle opening distance AOD 250 , AOD 500, Angle Recess Area ARA 250, ARA 500	8 week At the time of EUA to assess the anterior chamber parameters on ASOCT when the definitive diagnosis of glaucoma is made, & then compare it to non-glaucomatous children
To study whether the ASOCT findings in glaucomatous children correlates to the phenotype of glaucoma	8 week At the time of EUA to assess the anterior chamber parameters on ASOCT when the definitive diagnosis of glaucoma is made, & then compare it to non-glaucomatous children

Trial Locations

Locations (1): Postgraduate Institute of Medical Education and Research Chandigarh
🇮🇳
Chandigarh, CHANDIGARH, India
Postgraduate Institute of Medical Education and Research Chandigarh
🇮🇳Chandigarh, CHANDIGARH, India
Dr Sushmita Kaushik
Principal investigator
9814813207
sushmita_kaushik@yahoo.com