CTRI/2021/03/031798
Not yet recruiting
Phase 4
acetylcysteine as an adjunct to therapeutic hypothermia in the management of term or late preterm neonates with hypoxic ischemic encephalopathy to prevent the composite outcome of death or major neurodevelopment disability at 6 months postnatal age: a randomized, double-blind, placebo- controlled trial - HypNAC
Overview
- Phase
- Phase 4
- Intervention
- Not specified
- Conditions
- Health Condition 1: P039- Newborn affected by complication of labor and delivery, unspecified
- Sponsor
- Jawaharlal Institute of Postgraduate Medical Education and Research
- Status
- Not yet recruiting
- Last Updated
- 4 years ago
Overview
Brief Summary
No summary available.
Investigators
Eligibility Criteria
Inclusion Criteria
- •Inclusion criteria (The baby should meet criteria from either A or B, plus the criteria in C)
- •1\. Inborn babies with gestational age \>\= 36 weeks with ABG (umbilical cord or 1st postnatal hour) pH \<\=7 or Base deficit \>\= 12 meq/L
- •2\. Any one of the below mentioned criteria
- •i. APGAR \<\=5 at 10 min
- •ii. Assisted ventilation for at least 10 min after birth
- •iii. History of acute perinatal event\- intrapartum fetal distress, cord prolapse, placental abruption, maternal trauma, uterine rupture, cardiac arrest
- •3\. Presence of moderate or severe encephalopathy by clinical examination (Modified Sarnat staging).
Exclusion Criteria
- •Exclusion criteria
- •1\) Infants \>6 hours of age at the time of randomization.
- •2\) Major congenital abnormalities.
- •3\) Babies who do not have spontaneous respiration at 20 minutes of life
Outcomes
Primary Outcomes
Not specified
Similar Trials
Completed
Phase 2
Adjuvant N Acetylcysteine for Post Traumatuic Stress DisorderACTRN12618001784202Austin Health105
Active, not recruiting
Not Applicable
Effectiveness of acetylcysteine in ?rescue? therapy for Helicobacter pylori infection. Pilot Study - NDDuodenal and gastric ulcer recurrence with Helicobacter P. infectionMedDRA version: 9.1Level: LLTClassification code 10065231MedDRA version: 9.1Level: LLTClassification code 10051790EUCTR2009-011979-76-ITPOLICLINICO UNIVERSITARIO AGOSTINO GEMELLI
Completed
Not Applicable
acetylcysteine as a Preventive Measure for Contrast Induced Nephropathy in Intensive Care Patients with Renal InsufficiencyRenal insufficiencyUrological and Genital DiseasesISRCTN43635237Academic Medical Centre (AMC) (Netherlands)246
Not yet recruiting
Not Applicable
AC for treatment of Obsessive-Compulsive DisorderObsessive-compulsive disorder.Obsessive-compulsive disorderIRCT20170123032145N7Iran University of Medical Sciences44
Completed
Not Applicable
se of N-Acetylcysteine for prevention of Heart-Lung machine associated liver complication in cardiac surgeryCTRI/2018/05/014024Dr Ram Manohar Lohia institute of Medical Sciences Lucknow66