Dexmedetomidine vs. clonidine in delirious intensive care patients: a randomised open-label trial
Phase 4
Completed
- Conditions
- confusionDelirium10012221
- Registration Number
- NL-OMON38662
- Lead Sponsor
- Isala Klinieken
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 24
Inclusion Criteria
- age > 18
- no response on treatment with haloperidol (max. dose till 3x5mg)
- positive score CAM-ICU
Exclusion Criteria
- history of epilepsy, Parkinson's disease, hypokinetic rigid syndrome, or Lewy body dementia
- treatment with antipsychotic drugs
- pregnancy or breastfeeding
- CVA < 6months
- hypotension (< 90mmHg)
- bradycardia (<50/min)
- MAP < 60mmHg
- comatose patients (RASS -4 or -5)
- recent myocardial infarction of severe coronal insufficiency
- 2nd of 3rd degree AV-block or sicksinussyndrome
- known allergic reaction on clonidine of dexmedetomidine
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method
- Secondary Outcome Measures
Name Time Method