A Cluster Randomized Trial to Improve Weaning and Extubation From Mechanical Ventilation in Community Hospitals

Phase 3

Completed

• Conditions: Respiration, Artificial

• Registration Number: NCT00157287
• Lead Sponsor: Lawson Health Research Institute

Brief Summary

Protocol directed weaning has been shown to reduce the duration of mechanical ventilation for patients admitted to the intensive care unit (ICU) of tertiary centres. However, this benefit has not previously been studied in a community hospital setting. We therefore sought to evaluate the impact of an evidence-based weaning guideline on the outcomes for patients receiving mechanical ventilation in the ICUs of community hospitals in a cluster randomized controlled trial involving 11 community hospitals.

Detailed Description

Not available

Study Timeline

• Study Start: 2003-06
• Primary Completion: 2005-06
• Study First Submitted: 2005-09-08
• Study First Submitted QC: 2005-09-08
• Study First Posted: 2005-09-12
• Study Completion: 2006-04
• Status Verified: 2017-08
• Last Update Submitted: 2017-08-24
• Last Update Posted: 2017-08-25

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: Not specified

Inclusion Criteria

• patients ventilated for more than 24 hours

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Exclusion Criteria

• patients less than 16 years of age patients who receive only non-invasive ventilation patients chronically ventilated at time of ICU admission patients who will not be candidates for weaning from ventilation at time of admission If withdrawl of life support is imminent at the point the patient has been ventilated for 24 hours

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Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Primary Outcome Measures

Name	Time	Method
ICU length of stay

Secondary Outcome Measures

Name	Time	Method
complications (re-intubation within 48 hours, pneumonia within 48 hours)
Qulaity of life
duration of ventilation
ICU mortality
length of hospital stay
Hospital mortality
ICU readmissions

Trial Locations

Locations (11)

Joseph Brant Memorial Hospital; 🇨🇦 Burlington, Ontario, Canada

William Osler Health Centre (Brampton); 🇨🇦 Brampton, Ontario, Canada

Brant Community Health Systems; 🇨🇦 Brantford, Ontario, Canada

Guelph General Hospital; 🇨🇦 Guelph, Ontario, Canada

St. Joseph's Health Care; 🇨🇦 London, Ontario, Canada

Trillium Health Centre; 🇨🇦 Mississauga, Ontario, Canada

Lakeridge Health Corporation (Oshawa); 🇨🇦 Oshawa, Ontario, Canada

St. Joseph's Health Centre; 🇨🇦 Toronto, Ontario, Canada

Hotel Dieu of St. Joseph; 🇨🇦 Windsor, Ontario, Canada

North Bay General Hospital; 🇨🇦 North Bay, Ontario, Canada

Stratford General Hospital; 🇨🇦 Stratford, Ontario, Canada