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Clinical Trials/NCT06157593
NCT06157593Not yet recruitingNot Applicable

Neurally Adjusted Ventilatory Assist for Weaning From Invasive Mechanical Ventilation in Critically Ill Children: A Randomised Control Trial

Chulalongkorn University2 sites in 1 country60 target enrollmentStarted: February 2024Last updated:
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Conditions

Trial Snapshot

Phase
Not Applicable
Status
Not yet recruiting
Enrollment
60
Locations
2
Primary Endpoint
PICU length of stay
Study OverviewStudy DesignEligibility CriteriaOutcomesInvestigatorsSitesRecords & IdentifiersSimilar Trials

Study Overview

Brief Summary

The goal of this clinical trial is to compare weaning from mechanical ventilation in critically ill children. The main questions it aims to answer are:

  • Will weaning with neurally adjusted ventilatory assist (NAVA) mode ventilation result in shorter ventilator day than synchronised intermittent mandatory ventilation (SIMV) mode?
  • Will weaning with NAVA mode ventilation result in shorter paediatric intensive care unit (PICU) length of stay than SIMV mode? Participants will be randomised to NAVA or SIMV group for weaning from mechanical ventilation, then PICU outcomes from both groups will be collected, analysed and compared.

Study Design

Study Type
Interventional
Allocation
Randomized
Intervention Model
Parallel
Primary Purpose
Supportive Care
Masking
None

Eligibility Criteria

Ages
1 Month to 18 Years (Child, Adult)
Sex
All
Accepts Healthy Volunteers
Yes

Inclusion Criteria

  • •all critically ill children admitted to PICU

Exclusion Criteria

  • •failure to obtain informed consent

Outcomes

Primary Outcomes

PICU length of stay

Time Frame: immediately after PICU discharge

number of days patients remain in PICU

ventilator day

Time Frame: immediately after extubation

number of days patients receive mechanical ventilation

Secondary Outcomes

  • asynchrony index(20-minute period randomly captured from the day of extubation)

Investigators

Sponsor Class
Other
Responsible Party
Sponsor

Study Sites (2)

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