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Clinical Trials/NCT06157593
NCT06157593
Not Yet Recruiting
N/A

Neurally Adjusted Ventilatory Assist for Weaning From Invasive Mechanical Ventilation in Critically Ill Children: A Randomised Control Trial

Chulalongkorn University1 site in 1 country60 target enrollmentFebruary 2024

Overview

Phase
N/A
Intervention
Not specified
Conditions
Mechanical Ventilator Weaning
Sponsor
Chulalongkorn University
Enrollment
60
Locations
1
Primary Endpoint
PICU length of stay
Status
Not Yet Recruiting
Last Updated
2 years ago

Overview

Brief Summary

The goal of this clinical trial is to compare weaning from mechanical ventilation in critically ill children. The main questions it aims to answer are:

  • Will weaning with neurally adjusted ventilatory assist (NAVA) mode ventilation result in shorter ventilator day than synchronised intermittent mandatory ventilation (SIMV) mode?
  • Will weaning with NAVA mode ventilation result in shorter paediatric intensive care unit (PICU) length of stay than SIMV mode? Participants will be randomised to NAVA or SIMV group for weaning from mechanical ventilation, then PICU outcomes from both groups will be collected, analysed and compared.
Registry
clinicaltrials.gov
Start Date
February 2024
End Date
July 2025
Last Updated
2 years ago
Study Type
Interventional
Study Design
Parallel
Sex
All

Investigators

Responsible Party
Sponsor

Eligibility Criteria

Inclusion Criteria

  • all critically ill children admitted to PICU

Exclusion Criteria

  • failure to obtain informed consent

Outcomes

Primary Outcomes

PICU length of stay

Time Frame: immediately after PICU discharge

number of days patients remain in PICU

ventilator day

Time Frame: immediately after extubation

number of days patients receive mechanical ventilation

Secondary Outcomes

  • asynchrony index(20-minute period randomly captured from the day of extubation)

Study Sites (1)

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