Correlation Between Serum Anti-Müllerian Hormone & Müllerian Ducts Anomalies in Infertility
- Conditions
- Infertility
- Interventions
- Other: Anti Mullerian hormone level; Mullerian duct anomaly type
- Registration Number
- NCT02436538
- Lead Sponsor
- Ahmed M.Kamel
- Brief Summary
Anti-Müllerian hormone (AMH), also known as Müllerian inhibiting substance, is a dimeric glycoprotein that belongs to the transforming growth factor-beta family. It is involved in the regression of the Müllerian ducts during male fetal development. In the female, AMH is solely produced by the granulosa cells of preantral and small antral follicles, and regulates ovarian activity and follicular steroidogenesis
- Detailed Description
Following approval of the internal review board of Egyptian IVF-ET center, a retrospective analysis will be undertaken where a detailed review of the patients files who underwent intracytoplasmic sperm injection (ICSI) trials starting January 2010 till January 2015 will be done.
Patients with diagnosed mullerian anomalies will have their name , age ,duration of infertility, serum FSH, LH ,\& AMH levels recorded. The method of diagnosis (HSG, 3D/ultrasonography, hysteroscopy, or laparoscopy) will also be documented.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- Female
- Target Recruitment
- 226
- women with diagnosed mullerian anomlies whether clinically or through imaging
- previous ovarian surgery
- ovarian drilling
- polycystic ovarian syndrome (PCOs).
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Arm && Interventions
Group Intervention Description Mullerian duct anomalies Anti Mullerian hormone level; Mullerian duct anomaly type Anti Mullerian hormone level; Mullerian duct anomaly type
- Primary Outcome Measures
Name Time Method Correlation of serum anti-Müllerian hormone (AMH) level with mullerian anomalies 2 years
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
The Egyptian IVF-ET Center
🇪🇬Cairo, Maadi, Egypt