IRCT20210316050723N1
Completed
Phase 2
Evaluation of the effects of endometrial scratching on angiogenic and anti-angiogenic growth factors expression in unexplained repeated implantation failure (uRIF) patients
Overview
- Phase
- Phase 2
- Intervention
- Not specified
- Conditions
- Not specified
- Sponsor
- Iran University of Medical Sciences
- Enrollment
- 20
- Status
- Completed
- Last Updated
- 2 years ago
Overview
Brief Summary
No summary available.
Investigators
Eligibility Criteria
Inclusion Criteria
- •Infertile women with unexplained repeated implantation failure (unknown definite causes of RIF) failed to conceive after three or more embryo transfer cycles using high\-quality transferred embryos (at least one blastocyst ET cycle)
- •Age of 20 to 40 years
- •Body mass index (BMI) less than 25 kg/m2
- •Good response to stimulation of previous ovulation
- •Having at least two embryos with good grade
- •normal uterus results of hysterosalpingography (HSG) or hysteroscopy
- •Participant consent was required to join in the study and to complete the consent form
Exclusion Criteria
- •The thickness of the endometrium on the day of Human chorionic gonadotropin hormone injection is less than 7 mm
- •Women with congenital anomalies, intramural and subserosal myomas( larger than 5 cm)
- •Submucosal myoma
- •Women with endometrioma larger than or equal to 3 cm
- •With adhesions
- •With hydrosalpinx
- •Have previous uterine or ovarian surgery
- •Severe male factor infertility (sperm extraction from the testis, sperm freezing, sperm DNA fragmentation index equal to or above 16%) Patients with any specific medication
- •If the number of available embryos is less than 2 in the current cycle
- •Women with endometrial tuberculosis and those undergoing tuberculosis treatment
Outcomes
Primary Outcomes
Not specified
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