Evaluation of the effects of endometrial scratching on angiogenic and anti-angiogenic growth factors expression in unexplained repeated implantation failure (uRIF) patients

Iran University of Medical Sciences0 个研究点目标入组 20 人开始时间: 待定最近更新: 2024年3月6日

试验速览

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•Infertile women with unexplained repeated implantation failure (unknown definite causes of RIF) failed to conceive after three or more embryo transfer cycles using high-quality transferred embryos (at least one blastocyst ET cycle)
•Age of 20 to 40 years
•Body mass index (BMI) less than 25 kg/m2
•Good response to stimulation of previous ovulation
•Having at least two embryos with good grade
•normal uterus results of hysterosalpingography (HSG) or hysteroscopy
•Participant consent was required to join in the study and to complete the consent form

•The thickness of the endometrium on the day of Human chorionic gonadotropin hormone injection is less than 7 mm
•Women with congenital anomalies, intramural and subserosal myomas( larger than 5 cm)
•Submucosal myoma
•Women with endometrioma larger than or equal to 3 cm
•With adhesions
•With hydrosalpinx
•Have previous uterine or ovarian surgery
•Severe male factor infertility (sperm extraction from the testis, sperm freezing, sperm DNA fragmentation index equal to or above 16%) Patients with any specific medication
•If the number of available embryos is less than 2 in the current cycle
•Women with endometrial tuberculosis and those undergoing tuberculosis treatment
•Have a history of diabetes, thyroid disease, any endocrine, genetic, infection or autoimmune disorder
•Abnormal Pre-implantation Genetic Test (PGT) Results
•Any specific medication
•Failure to return the patient to prepare an endometrial sample
•Women with severe pain during obtaining of tissue samples or the possibility of infection

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