Switching to E-cigarette After PCI

Completed

• Conditions: Coronary Artery Disease
• Interventions: Behavioral: Switching to E-cigarette; Behavioral: Smoking cessation

• Registration Number: NCT06338761
• Lead Sponsor: Samsung Medical Center

Brief Summary

Despite the increasing popularity of electronic cigarettes (E-cigarettes), the prognostic impact of switching to E-cigarettes in smokers with coronary artery disease (CAD) who underwent percutaneous coronary intervention (PCI) remains uncertain.

Detailed Description

Recently, several studies have reported that, although lower than combustible cigarette users, E-cigarette users had a significantly higher risk of future myocardial infarction (MI) or cardiovascular disease compared with non-smokers or quitters. However, because all previous studies has focused on the general healthy population, these results cannot be extrapolated for patients who already proven atherosclerotic cardiovascular disease (ASCVD), such as undergoing percutaneous coronary intervention (PCI) for coronary artery disease (CAD). Although Busch et al. previously reported that a significant minority of patients are using E-cigarettes post-acute coronary syndrome smokers, a paucity of data exists regarding the impact of such transitions on clinical outcomes in current smoker patients with CAD who have undergone PCI. In light of these considerations, the current study sought to address this gap in knowledge by evaluating the prognostic implications of smoking habit changes, including E-cigarette use, among CAD patients with current smoking status following PCI.

Study Timeline

• Study Start: 2024-01-01
• Study First Submitted: 2024-03-24
• Study First Submitted QC: 2024-03-24
• Study First Posted: 2024-04-01
• Primary Completion: 2024-12-31
• Study Completion: 2025-03-15
• Status Verified: 2025-05
• Last Update Submitted: 2025-05-17
• Last Update Posted: 2025-05-21

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 17973

Inclusion Criteria

• patients who underwent health screening 3 years before and after the PCI

Exclusion Criteria

• history of cancer
• history of ischemic stroke
• died within the first 3 months of follow-up from the index date
• Newly developed acute MI or received additional PCI or CABG from the index PCI date to the study index date

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
Switching to E-cigarette	Switching to E-cigarette	switching to E-cigarette users after PCI
Quitter	Smoking cessation	quitters after PCI

Primary Outcome Measures

Name	Time	Method
MACE	5 years after PCI	Major adverse cardiac event

Secondary Outcome Measures

Name	Time	Method
Cardiovascular death	5 years after PCI	death from cardiovascular cause
Repeat revascularization	5 years after PCI	additional PCI or CABG
All-cause death	5 years after PCI	death from any cause
Spontaneous myocardial infarction	5 years after PCI	MI with hospitalization

Trial Locations

Locations (1)

Samsung Medical Center; 🇰🇷 Seoul, Korea, Republic of