Hyperpolarized 129-Xenon MRI in Fibrosing Interstitial Lung Disease
- Conditions
- Progressive Fibrosing Interstitial Lung DiseasesTherapeutic area: Diseases [C] - Respiratory Tract Diseases [C08]Therapeutic area: Analytical, Diagnostic and Therapeutic Techniques and Equipment [E] - Investigative Techniques [E05]
- Registration Number
- CTIS2022-502512-36-00
- Lead Sponsor
- Aarhus University
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- All
- Target Recruitment
- 30
Patients diagnosed with IPF or fibrotic ILD who fulfills PPF criteria, and are prescribed antifibrotic treatment., Age 18-90, Cognitively able to understand and participate in the study, Pre-menopausal women must be confirmed non-pregnant by an onsite test.
Contraindications for MRI (Pacemaker, neurostimulator or cochlear implant; Metal foreign bodies such as fragments and irremovable piercings; Unsafe medical implants (safety of heart valves, hips and the like must be confirmed); Intrathoracic clips or coils; Cardiac pacemakers; Claustrophobia; Largest circumference including arms > 160 cm), Contraindications to gadolinium contrast (eGFR < 30 mL/min/1.73m2; Previous adverse reactions to gadolinium), Overlapping emphysematic disease where the emphysema-component outweighs the fibrosis, Unable to perform breath-hold of minimum 20 seconds., Allergy to Xenon, Breast feeding, Evidence of ongoing respiratory infections at time of MR examinations
Study & Design
- Study Type
- Interventional clinical trial of medicinal product
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method
- Secondary Outcome Measures
Name Time Method