An investigation to explore the use of a type of MRI scan using an inhaled gas in identifying lung damage associated with long COVID sufferers
- Conditions
- ong COVIDInfections and Infestations
- Registration Number
- ISRCTN14304264
- Lead Sponsor
- niversity of Oxford
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Ongoing
- Sex
- All
- Target Recruitment
- 400
1. Participant is willing and able to give informed consent for participation in the study
2. Aged 18 years or above
3. One of the following criteria:
3.1. Microbiological evidence of COVID-19 infection OR
3.2. Diagnosis of long COVID or 'post-COVID syndrome' (as defined by NICE 2020) made through specialised assessment at a designated long COVID clinic
1. Participants who are pregnant, lactating or planning pregnancy during the course of the study
2. Known or identified chronic renal impairment, with EGFR below 60 ml/min – if necessary this renal function will be measured according to local hospital policy
3. Known prior contrast media reaction
4. Inability to lie flat for imaging
5. Contraindications to MRI examinations as locally determined
6. Any other reason, as determined by the study investigators, that renders the participant ineligible for the study
Study & Design
- Study Type
- Observational
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <br> 1. Diffusion and or perfusion defects detected using HPX-pMRI at baseline and if abnormal at 3 and 12 months<br> 2. The determination of whether detected abnormalities correlate with symptoms of breathlessness measured using lung function tests and questionnaires at baseline and if the HPX-pMRI scans are abnormal at baseline, 3 and 12 months<br> 3. The degree of pulmonary damage and change detected on follow up HPX-pMRI scanning at 3 and 12 months<br>
- Secondary Outcome Measures
Name Time Method Cardiac MRI abnormalities detected using a single cardiac MRI sequence at baseline, 3 and 12 months