Isolated ACTH Deficiency in Patients With Hashimoto Thyroiditis
- Registration Number
- NCT00552487
- Lead Sponsor
- University of Wuerzburg
- Brief Summary
The purpose of this study is to determine whether patients with Hashimoto thyroiditis and impaired well-being may have a partial secondary adrenocortical insufficiency.
- Detailed Description
Many patients with Hashimoto thyroiditis who are correctly substituted with thyroid hormones have an impaired well-being. in some people an isolated ACTH deficiency was found.
In this study a 1 µg ACTH test is performed to evaluate the adrenocortical function.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 62
Inclusion Criteria
- Hashimoto thyroiditis euthyreot thyroid function with levothyroxin therapy written informed consent
Exclusion Criteria
-
• hypothyroidism of other origin
- pregnancy and lactation
- oral contraception
- glucocorticoid therapy during the last 2 months
- History of malignancy or chronic infections (Hepatitis, HIV)
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description 3 synacthen patients with Hashimoto disease an impaired well-being receive a 1 µg ACTH stimulation test 4 synacthen patients with Hashimoto disease and negative TPO antibodies receive a 1µg ACTH stimulation test 1 synacthen healthy people without Hashimoto disease receive a 1µg ACTH stimulation test 2 synacthen patients with Hashimoto disease with well being receive a 1 µg ACTH stimulation test
- Primary Outcome Measures
Name Time Method serum cortisol-peak 30 min after ACTH-stimulation 30 minutes
- Secondary Outcome Measures
Name Time Method serum DHEA-peak 30 min. after ACTH-stimulation,DHEA-S, ACTH 30 minutes
Trial Locations
- Locations (1)
University of Wuerzburg, Department of Endocrinology
🇩🇪Wuerzburg, Bavaria, Germany