Tetracosactide
- Generic Name
- Tetracosactide
- Brand Names
- Cortrosyn, Synacthen
- Drug Type
- Small Molecule
- Chemical Formula
- C136H210N40O31S
- CAS Number
- 16960-16-0
- Unique Ingredient Identifier
- 72YY86EA29
- Background
Tetracosactide (also known as Cosyntropin) is a synthetic peptide that is identical to the 24-amino acid segment (sequence: SYSMEHFRWGKPVGKKRRPVKVYP) at the N-terminal of adrenocorticotropic hormone. ACTH (1-24), a segment similar in all species, contains the biological activity that stimulates production of corticosteroids in the adrenal cortex. Tetracosactide exhibits the same activity as natural ACTH with regard to all its biological activities. The complex results in a product whose absorption in man is effected over a longer period of time as compared to corticotropin. Therefore, therapy may be maintained with less frequent administration.
- Indication
For use as a diagnostic agent in the screening of patients presumed to have adrenocortical insufficiency.
- Associated Conditions
- Acute Gouty Arthritis, Acute Rheumatic Fever, Adrenal Insufficiency, Ankylosing Spondylitis (AS), Bell's Palsy, Choroiditis, Conjunctivitis, Dermatomyositis (DM), Iritis, Keratitis, Lupus Erythematosus, Multiple sclerosis exacerbation, Nephrotic Syndrome, Ophthalmia, Sympathetic, Optic Neuritis, Panhypopituitarism, Pemphigus, Periarteritis nodosa, Psoriatic Arthritis, Rheumatoid Arthritis, Scleroderma, Still's Disease, Ulcerative Colitis, Uveitis, Acquired hemolytic jaundice, Exfoliative erythroderma
- Associated Therapies
- -
A Novel Approach to Infantile Spasms
- Conditions
- Infantile Spasm
- Interventions
- First Posted Date
- 2017-11-20
- Last Posted Date
- 2021-05-27
- Lead Sponsor
- University of Colorado, Denver
- Target Recruit Count
- 394
- Registration Number
- NCT03347526
- Locations
- 🇺🇸
Cook Children's Medical Center, Fort Worth, Texas, United States
🇺🇸Atrium Health, Charlotte, North Carolina, United States
🇺🇸Columbia University Medical Center, New York, New York, United States
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