Resistant bacteria of stool causing infection at other sites in ACLF patients.
- Conditions
- Health Condition 1: K769- Liver disease, unspecified
- Registration Number
- CTRI/2020/05/025096
- Lead Sponsor
- Institute of Liver and Biliary Sciences
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Open to Recruitment
- Sex
- Not specified
- Target Recruitment
- 0
1. Patients with Acute on Chronic Liver Failure admitted to the ward/High Dependency Unit/Intensive Care Unit.
1.Patients on immunosuppressant medications or on daily steroids (excluding inhaled steroids) or >2 weeks.
2.Patients with additional primary or acquired immunosuppressive states like hypogammaglobinemia, post-splenectomy, human immunodeficiency virus (HIV) infection etc.
3.Neutropenia defined as absolute neutrophil count or total white blood cell count (WBC) <500/mm3
4.Patients with extra-hepatic malignancy or on cytotoxic chemotherapy.
5.Patients with ileus, bowel hypomotility, severe constipation requiring laxatives/purgatives or enemas to evacuate.
6.Patients with fresh or altered blood in stools.
7.Patients with anatomical predisposition to infection/ bacterial seeing like prosthesis or foreign body. Patients with exfoliative skin conditions, significant mucosal ulcerations, or skin ulcers. Patients who have received > 2 weeks of antibiotics before current admission.
8.Pregnant patients.
Study & Design
- Study Type
- Observational
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Fecal isolation rates of carbapenem resistant gram negative bacterial species (CR-GNB) among hospitalized ACLF patientsTimepoint: Day 28
- Secondary Outcome Measures
Name Time Method