Prediction of Fluid Responsiveness in Atrial Fibrillation Patients Who Underwent Valvular Heart Surgery: Peep-induced Increase in Central Venous Pressure vs. Passive Leg Raising

Not Applicable

Completed

• Conditions: Valvular Heart Surgery
• Interventions: Procedure: passive leg raising(PLR); Procedure: peep induced CVP

• Registration Number: NCT02224378
• Lead Sponsor: Yonsei University

Brief Summary

Dynamic indices of preload depending on the heart-lung interaction require sinus rhythm and cannot be applied to patients with atrial fibrillation. PEEP-induced increase in central venous pressure (CVP) was shown to be a valid predictor of fluid responsiveness after cardiac surgery in patients with sinus rhythm, and was speculated to be of value in patients with rhythm other than sinus. The aim of this study is to assess the predictability of PEEP-induced increase in CVP and passive leg raising (PLR)-induced changes in stroke volume index (SVI) on fluid responsiveness in patients with atrial fibrillation following valvular heart surgery.

Detailed Description

Not available

Study Timeline

• Study Start: 2012-03
• Study First Submitted: 2014-08-19
• Study First Submitted QC: 2014-08-21
• Study First Posted: 2014-08-25
• Primary Completion: 2014-10
• Study Completion: 2014-10
• Status Verified: 2015-03
• Last Update Submitted: 2015-03-31
• Last Update Posted: 2015-04-01

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 44

Inclusion Criteria

1. age ≥20
2. atrial fibrillation patients who underwent elective valvular heart surgery

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Exclusion Criteria

1. age < 20
2. LV ejection fraction < 40%
3. any pulmonary disease
4. end stage renal disease
5. high intrabdominal pressure patient
6. contraindication of passive leg raising
7. deep vein thrombosis

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Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
passive leg raising(PLR)	passive leg raising(PLR)	-
peep induced CVP	peep induced CVP	-

Primary Outcome Measures

Name	Time	Method
fluid responsiveness	1hr after arriving at ICU	1. ventilator peep setting was adjusted to 0cmH2O as baseline; 2. Then peep was increased to 10cmH2O for 5 min.; 3. We set peep to baseline 0cmH2O again, making patients to semirecumbent position following passive leg raising at 30 degree for 5 min.; 4. After that, 300 ml of hydroxyethyl starch 130/0.4 was infused in the supine position for 10-20 min and haemodynamic variables including SVI were assessed 5 min after completion of fluid challenge.

Trial Locations

Locations (1)

Department of Anesthesiology & Pain Medicine, Yonsei university college of medicine; 🇰🇷 Seoul, Korea, Republic of