Clinical trial of YAG laser vitreolysis for floater caused by Weiss ring

Phase 4

• Conditions: floater caused by Weiss ring

• Registration Number: JPRN-UMIN000036588
• Lead Sponsor: The Study Group for Laser Vitreolysis

Brief Summary

In the YAG laser vitreolysis group, the 10-point visual disturbance score improved by 2.5 vs 0.4 in the sham group (difference, -2.1; 95% CI, -3.3 to -0.9; P < .001). The YAG laser vitreolysis group reported greater symptomatic improvement (54%) than controls (18%) (difference, 36.1; 95% CI, 20.0-52.3; P < .001).

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Completion: 2018-06-30
• Study Start: 2019-04-24
• Last Update Posted: 17 October 2023

Recruitment & Eligibility

• Status: Complete: follow-up continuing
• Sex: All
• Target Recruitment: 49

Inclusion Criteria

Not provided

Exclusion Criteria

1) fellow eye with best corrected visual acuity bellow 0.4(20/50) 2) history of retinal break, retinal detachment, uveitis in the study eye 3) history of diabetic retinopathy, macular edema, retinal vein occlusion, or aphakia in the study eye 4) ongoing treatment of glaucoma or ocular hypertension by more than 2 kinds of glaucoma topical medication, history of glaucoma surgery in the study eye

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Subjective change measured by visual questionnaire

Secondary Outcome Measures

Name	Time	Method
a) visual acuity b) ultrasound B scan c) optical coherence tomography; OCT d) fundus photo image e) slit lamp examination, indirect ophthalmoscope,intra ocular pressure f) National Eye Institute Visual Functioning Questionnaire 25(VFQ-25)