A Pilot Study Evaluating Penicillin G and Ceftriaxone as Therapies for Presumed Neurosyphilis in HIV Seropositive Individuals
- Conditions
- NeurosyphilisHIV Infections
- Registration Number
- NCT00000648
- Brief Summary
To provide information on the response of HIV infected, neurosyphilis patients to the currently recommended treatment for neurosyphilis; to determine whether possible co-infection with both HIV and syphilis makes more difficult the diagnosis of syphilis; to explore the usefulness of an alternative treatment which, if effective, would permit outpatient treatment for neurosyphilis that until now required prolonged hospitalization.
Studies suggest that syphilis treatment failures may be more common in HIV infected patients than in patients without HIV infection and that treatment failures occur due to and/or are displayed as central nervous system (CNS) involvement. Very little is known about the best treatment course for neurosyphilis in patients who are also infected with HIV.
- Detailed Description
Studies suggest that syphilis treatment failures may be more common in HIV infected patients than in patients without HIV infection and that treatment failures occur due to and/or are displayed as central nervous system (CNS) involvement. Very little is known about the best treatment course for neurosyphilis in patients who are also infected with HIV.
HIV infected patients who are presumed to have neurosyphilis or have definitive neurosyphilis are treated for the neurosyphilis with either penicillin G or ceftriaxone. Patients are treated for 10 days and followed for 50 weeks after treatment. Patients receiving penicillin G are hospitalized while receiving the penicillin. Patients receiving ceftriaxone are treated on an inpatient basis for at least the first three days and may then be discharged to receive outpatient treatment. During treatment, patients are permitted to take antiretroviral drugs or other drugs for opportunistic infections except for drugs that are antisyphilitic. Lumbar punctures will be performed.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 100
Not provided
Not provided
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Primary Outcome Measures
Name Time Method
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (42)
Northwestern Univ Med School
🇺🇸Chicago, Illinois, United States
Rush Presbyterian - Saint Luke's Med Ctr
🇺🇸Chicago, Illinois, United States
Beth Israel Deaconess Med Ctr
🇺🇸Boston, Massachusetts, United States
Harbor UCLA Med Ctr
🇺🇸Torrance, California, United States
Florida Keys Memorial Hosp
🇺🇸Key West, Florida, United States
Johns Hopkins Hosp
🇺🇸Baltimore, Maryland, United States
Montefiore Drug Treatment Ctr / Bronx Municipal Hosp
🇺🇸Bronx, New York, United States
Baystate Med Ctr of Springfield
🇺🇸Springfield, Massachusetts, United States
Bronx Municipal Hosp Ctr/Jacobi Med Ctr
🇺🇸Bronx, New York, United States
Montefiore Family Health Ctr / Bronx Municipal Hosp
🇺🇸Bronx, New York, United States
Samaritan Village Inc / Bronx Municipal Hosp
🇺🇸Bronx, New York, United States
Jack Weiler Hosp / Bronx Municipal Hosp
🇺🇸Bronx, New York, United States
North Central Bronx Hosp / Bronx Municipal Hosp
🇺🇸Bronx, New York, United States
SUNY / Health Sciences Ctr at Brooklyn
🇺🇸Brooklyn, New York, United States
Montefiore Med Ctr / Bronx Municipal Hosp
🇺🇸Bronx, New York, United States
Nassau County Med Ctr
🇺🇸East Meadow, New York, United States
Montefiore Med Ctr Adolescent AIDS Program
🇺🇸Bronx, New York, United States
Bellevue Hosp / New York Univ Med Ctr
🇺🇸New York, New York, United States
SUNY / Erie County Med Ctr at Buffalo
🇺🇸Buffalo, New York, United States
Saint Luke's - Roosevelt Hosp Ctr
🇺🇸New York, New York, United States
Univ of Rochester Medical Center
🇺🇸Rochester, New York, United States
Columbia Presbyterian Med Ctr
🇺🇸New York, New York, United States
Univ of North Carolina
🇺🇸Chapel Hill, North Carolina, United States
SUNY / State Univ of New York
🇺🇸Syracuse, New York, United States
Carolinas Med Ctr
🇺🇸Charlotte, North Carolina, United States
Wake Med Ctr / Univ of North Carolina
🇺🇸Chapel Hill, North Carolina, United States
Thomas Jefferson Univ Hosp
🇺🇸Philadelphia, Pennsylvania, United States
Univ of Pennsylvania at Philadelphia
🇺🇸Philadelphia, Pennsylvania, United States
Med Univ of South Carolina / UNC
🇺🇸Charleston, South Carolina, United States
Med Service
🇺🇸Miami, Florida, United States
Univ of California / San Diego Treatment Ctr
🇺🇸San Diego, California, United States
Methodist Hosp of Indiana / Life Care Clinic
🇺🇸Indianapolis, Indiana, United States
Miami Veterans Administration Med Ctr
🇺🇸Miami, Florida, United States
Univ of Washington
🇺🇸Seattle, Washington, United States
Univ of Miami School of Medicine
🇺🇸Miami, Florida, United States
Indiana Univ Hosp
🇺🇸Indianapolis, Indiana, United States
Univ of Cincinnati
🇺🇸Cincinnati, Ohio, United States
Northwest Family Ctr at the Harbor View Med Ctr
🇺🇸Seattle, Washington, United States
Univ of Alabama at Birmingham
🇺🇸Birmingham, Alabama, United States
San Francisco Veterans Administration Med Ctr
🇺🇸San Francisco, California, United States
Yale Univ / New Haven
🇺🇸New Haven, Connecticut, United States
Robert Wood Johnson Med School/UMDNJ
🇺🇸New Brunswick, New Jersey, United States