Does dexamethasone influence blood cortisol levels after laparoscopic cholecystectomy?

Phase 3

• Conditions: aparoscopic cholecystectomy; Gallstone disease; Cholecystitis; Postoperative nausea and vomiting; Postoperative pain; Laparoscopic cholecystectomy; Oral and Gastrointestinal - Other diseases of the mouth, teeth, oesophagus, digestive system including liver and colon

• Registration Number: ACTRN12607000406404
• Lead Sponsor: St Vincents Health Melbourne

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2007-08-07
• Last Update Posted: 13 January 2020

Recruitment & Eligibility

• Status: ot yet recruiting
• Sex: All
• Target Recruitment: 40

Inclusion Criteria

Patients undergoing laparoscopic cholecystectomy with none of the exclusion criteria.

Exclusion Criteria

Non English speakingInsulin requiring diabetesPatients receiving exogenous steroid treatment for other illness.Unable to receive standardised inhalational anaesthesia.

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Perioperative cortisol levels [Measured immediately preoperatively, 20 minutes after administration of dexamethasone and 8 hours postoperatively.]

Secondary Outcome Measures

Name	Time	Method
Pain scores using visual analgogue scale (VAS) or numeric rating scale (NRS).[These endpoints will be measured twice daily on the operative day and for 2 days postoperatively.];Episodes of nausea[These endpoints will be measured twice daily on the operative day and for 2 days postoperatively.];Episodes of vomiting[These endpoints will be measured twice daily on the operative day and for 2 days postoperatively.];Analgesia and antiemetic use[These endpoints will be measured twice daily on the operative day and for 2 days postoperatively.]