Intravenous Dexamethasone for Preventing Post Operative Nausea and Vomiting in Total Abdominal Hysterectomy: A Randomized Control Trial

Phase 1

Completed

• Registration Number: TCTR20230410007
• Lead Sponsor: Khon Kaen Hospital Institute Review Board in Human Research

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Completion: 2023-03-31
• Study Start: 2023-04-10
• Last Update Posted: 19 August 2024

Recruitment & Eligibility

• Status: Completed
• Sex: Female
• Target Recruitment: 86

Inclusion Criteria

1.Women age >18 years old.
2.Patient who underwent benign total abdominal hysterectomy with or without
adnexal surgery.
3.Patient who understands Thai language.

Exclusion Criteria

1.Known hypersensitivity to dexamethasone.
2 .There are conditions that might influence gastrointestinal mobility including abdominal bowel surgery, previous abdominal irradiation.
3.Other gastrointestinal disorders (pancreatitis, peritonitis, hypothyroid, chronic use of opiate, musculoskeletal disorders and chronic use of drugs which impact intestinal peristalsis).
4.Patient underlying of diabetes who got poor control of glycemic control having HbA1Cmore than 8, moderate degrees of diabetic of retinopathy, impaired of visual acuity, history of wound resulting from diabetes at foot, history of foot amputation, claudication of lower limbs.
5.Patient who got immunocompromised host (Tubercolosis, Viral Infection)
6.Intraoperation blood loss of more than 1,000 ml or blood loss that requires blood transfusion.

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Incidence of PONV at 24 hours after surgery (n%) 24 hours after surgery Patient reported outcome using a questionnaire interview

Secondary Outcome Measures

Name	Time	Method
Additional antiemetics requirements(n%) 24 hours after surgery Patient reported outcome using a questionnaire interview,Additional analgesic requirements(n%) 24 hours after surgery Patient reported outcome using a questionnaire interview,Side effects of dexamethasone(n%) 24 hours after surgery Patient reported outcome using a questionnaire interview,Analgesic effect measure by VAS mean(SD) 24 hours after surgery Patient reported outcome using Visual Analogue Scale,The duration of hospital stay (hours) mean (SD) 24 hours after surgery Patient reported outcome using a questionnaire interview